Diagnosed with tremor intensive PD 2001. Started Sinemet end 2012, 3x100mg /d as I was getting weaker. I sailed along OK for about one year, then suddenly one to two hours after taking a dose I would go into almost a convulsion like state with intense tremor and weakness. I learned that I was not allergic as I first thought, but that the dose was wearing off.
After experimenting for about six months I noticed that in the mornings I felt good without the meds, moving OK, voice is good, balance is good - but slowly the tremor would increase and I would start feeling weaker. So I decided to take my dose 150 mg Prolopa (same as Sinemet) at 2pm, 4 pm and 7 pm with added comtan to each dose. This seemed to work fine for several months, I would have the odd meltdown when I forgot to take meds. The meds effect my voice and speech (slurry).
But over the past week I have had to add an extra dose as it is wearing off much quicker.
Am I doing the wrong thing by going without medication for aprox 14 hrs then suddenly hitting myself with a dose? Is this almost like starting out afresh every day.
Does anyone know if the dopamine builds up in the system, or how long it takes to clear the system?
Any advice is appreciated.