Is Lynparza only for our ladies caring the BRACA gene

[Annr5h]

Hi ladies is anybody on Lynparza that don’t have the BRACA gene? Or is it just for people with the gene.

[Katmal-UK]

They were trialling it for non brac ladies x

[Annr5h in reply to Katmal-UK]

Do you know if they intend to use it on non BRACA ladies x

[Purple-iris in reply to Annr5h]

I think they use a different PARP for non BRACA called Niraparib but it’s only available for recurrence.

Got the info below from the OC A patient hub incase useful

Kim x

There are currently two PARP inhibitors available to treat ovarian cancer: olaparib and niraparib.

Olaparib (Lynparza®) is used to treat some types of advanced ovarian, Fallopian tube or primary peritoneal cancer in women with a BRCA1/2 gene mutation following first- or third-line treatment.

Niraparib is used to treat high grade serous non-mucinous epithelial ovarian cancer. It’s available as a maintenance therapy for women who have a platinum-sensitive recurrent ovarian cancer, women who have responded to a round of chemotherapy since their cancer returned.

It is available to women regardless of whether they have a BRCA gene mutation or not. Women with and without a BRCA gene mutation are eligible for the drug if they haven’t previously been prescribed a PARP inhibitor as part of their treatment.

Niraparib can be accessed by women across the UK.

[Annr5h in reply to Purple-iris]

I’ve had Niraparib and it hasn’t worked for me was only on it for 4 months and my cancer returned unfortunately. Just was wondering if Lynparza was available. But I get the feeling I won’t get a PARP offered again. Now on weekly taxol for 22 weeks. Trying to look into every avenue at the moment. Keep well lovely ladies

[Purple-iris in reply to Annr5h]

Sorry to hear the niraparib didn’t work for you. This disease is so individual it’s worth trying everything available.

I hope the taxol isn’t causing too many side effects and is stabilising the recurrence. It’s definitely worth asking about the Olaparib. Maybe Anna on the support line could help ?

Love and best wishes that you get back to stable disease and remission.

Kim x

[Katmal-UK in reply to Annr5h]

Thats what my oncologist said, yes.