How long do PPIs take to work?

[ReallyWondering]

I have acid reflux and I’ve been on Famotidine, Esomeprazole, each for 2 weeks, and now omeprazole for 6 weeks. Cut out all acidic and spicy food. I still have heartburn every day. I usually get it at around noon. How long do these PPIs take to work? Just wondering if they’re not even helping. I also now have a B12 deficiency which I’m getting weekly shots for.

[Jumpey]

They didn't work for me either. They would have helped by now. You may want to consider surgery if your lower oesophagal sphincter isn't working.

[ParkSchool5]

Hi, have you tried taking the Omeprazole an hour before your main meal rather than in the morning? It has helped me to have it before meals. Good luck.

[ReallyWondering in reply to ParkSchool5]

I have not. However my heartburn is not usually after I eat, it happens more on an empty stomach.