Hi all, I was just wondering if anyone else experiences increased fatigue when taking Sulfazalasine. Im also taking mtx (1 x weekly), hydroxy, prednisolne, folic acid (1 x weekly), Tramadol and fluxotine. In the past week, I have had the most awful fatigue, I think I have ever experienced since my diagnosis in January (by GP, confirmed March by Rhuemy). Has anyone else experienced similar. I have spoken to my Rheumy nurse, who has increased the prednisolne, which she says may help. My ESR is still high,so I know my disease is still very active, along with the pain in hands, wrists and knees. While I'm having a moment (lol) does anyone get restless legs? Mine are driving me insane!! They get worse the more pain I get in my knees!!