Hi am on triple meds methotrexate hydrohex and sulfasalazine.
Advised to choose between jak tablets or adulimumbad injection.Either way appreciate both potentialy dodgy.
Any advice or wisdom from anyone who has trialed one or other and in particular switched from both.
such a gamble,Cannot decide!
Thanks,Nicho.
If you put both of those into the search box and filter for NRAS then the past posts about them will come up. Why do you think they are potentially dodgy? Many here are on JAK’s or biologics so hopefully you will be reassured. Does your rheumy not have a preference for you as I’ve never been told to choose myself😊
Agree, and I’d say uncontrolled RA is as much a concern as moving to a biologic, although I appreciate many of us have had our worries re biologics, myself included but the alternative was not a good prospect to stay as I was.
I started on Adalimumab in 2006, initially Humira and now Amgevita, it has transformed my life. Prior to this I couldn't pick up a mug or walk beyond a shuffle. Now I have just returned from skiing in Austria. I no longer have to take Sulfasalazine and have halved my dose of methotrexate. I haven't tried JAK inhibitors so can't help you there. I just felt very blessed to be offered a TNF inhibitor at a time when they were very hard to obtain. I'm not sure why you feel they are dodgy, certainly there are risks but uncontrolled disease also carries very high risks. I note your user name is " Wantplaytennis", I did and was missing playing dreadfully when I was at my worst. I remember my consultant saying "I'll get you playing again", he did and it was Humira that achieved it.
Hi thanks for reply re your experience.Tennis and skiing is also me,so encouraging.
Not sure where to access search box and filter as suggested.will try again
Search box is top right on your screen.
I have just started Jak tablets, Filgotinib,not 7 days yet but I can uncurl my hand and do not feel as stiff in the morning.plus I didn’t want another injection to add to Methotrexate.
Good luck with your research! Adalimumab has been a life changer for me. I’ve never been a tennis player but am currently training for a marathon 😊.
The two medications work in slightly different ways, so that if one doesn't work, the other one might. JAK inhibitors are the easiest in that most are tablets, so if you're not keen on injections that might sway your choice. They are both 'biological' treatments, so the procedure for screening before use (for latent infections that might be reactivated) is the same anyway.
Rheumatoid Disease is a collection of diseases lumped together as we don't (yet) have the knowledge to identify exactly which part of our immune system is overactive. It has to be trial and error currently to try to find the pathway that needs suppressing. What works for me might not work for you (adalimumab working well for me currently).
Hi, as others have said it's a personal thing and one drug will work better for some than others. I have been taking biologics for 15 years and have to say they are marvellous. My only advice would be that if you travel much, it is much easier to travel with tablets than to keep injections stored at the correct temperature. Hope whatever you choose works well for you.
Was on methotrexate and sulfasalazine but moved to Etanercept Biosimilar Benepali 5 years ago.The biological was life changing. Much less pain and significantly improved mobility.
Previously, when I had severe hand and chest joint pains I was placed on methotrexate (17.5mg weekly). Then I was offered Amgevita which I started taking. Since then I've just been on Amgevita (40mg) every 3 weeks. I have been able to walk and move my hands as normal.
I only stopped Amgevita everytime I needed to take the vaccination (influenza/covid) - but was still able to function as normal.
Also haven't gotten any side effects that methotrexate use to give me.
Inflammatory Arthritis
Methotrexate and nausea 
