tynycwmmarchhywel

[tyncwmmarchhywel]

hi folks just a thought has any one gone back on methotrexit after coming off the first time due to side effects and if how did it work thank you

[sylvi]

I had no trouble with side effects when i was on MTX, but i can't take it now as i had a ground glass appearance on my lungs and six months later when i had another x-ray it had gone. xxx

[Tkat10]

Same side effects again so came back off. On my never again drug list, works but at a quality of life cost.

[Joanneforbes]

Hello 👋 yes I started on methotrexate it caused me liver issues then diagnosed with Gilbert’s disease but after a break of couple of months I was in a lot of pain I was put on it again . I was a little worried about it injection form but apart from nausea it’s been better and finally working 👍🏻 Good luck x

[janmary]

I had bad side effects on tabs, had break , back on tabs, same side effects . Had another break went on injections with no recurrence of the side effects. Still on Metoject 10 years later

[oldtimer]

I had the same side effects! Eventually after transferring to the injections at a lower dose (same problems) went on azathioprine (as had allergic reactions to other DMARDs). Looking back, I think I put up with the side effects for a surprisingly long time and it was only when the dentist, looking at my enormous mouth ulcers, said 'You should change medication' that I had the courage to challenge the rheumatologist.

[tyncwmmarchhywel]

thank you all for your comments very interesting

[Blodynhaul]

Su' mae? Sut dach chi?! siarad Cymraeg?

Hi TynCH (excuse abbrev.), I was on MTX for about 13 years and came off it a few times over that period due to it affecting the liver & also chronic nausea. Each time, after a few months off it, then going back on it, I was fine again for a while, but still had nasty nausea a couple of days a week, until the last year or two there was permanent nausea and feeling poisoned by it. Going onto injections didn't help, so eventually was put onto Leflunamide (& had no problem onthat at all, until it stopped working for some reason after 7 years).

Having read others' accounts of MTX and the use of Folic Acid, I was only ever taking it once a week (5mg) and no one ever suggested to me to take more of it, but I notice on this forum some people take it or have taken it up to 6 days a week. I don't know if that would have decreased the nausea misery for those years or not (bit late now!), but could be worth bearing in mind if the same thing happens to you.

All the best, wish you well, Hwyl 😁💖👍

[Hidden]

It is difficult to compare like with like when talking about Methotrexate as many people will be on various doses anywhere between 7.5mg (very low dose) to 25mg dose. Also there are differences between taking methotrexate orally versus subcutaneous. Many people report much less side effects on injectable methotrexate than on oral tablets. It's not clear which you are on. If you'd like to find out more about methotrexate by injection nras.org.uk/resource/methot...(Not working as expected?)