Side effects on Sulfasalazine: Hi, I’ve just this week... - NRAS


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Side effects on Sulfasalazine

Emle143 profile image
16 Replies

Hi, I’ve just this week reached my 4 tablets a day on Sulfasalazine. Since then I can’t seem to have any caffeine or sugar as I’ve started having bad heart palpitations that last about 6-8 hours. I can’t find anywhere online that this is a thing, It’s making me feel very out of breath, tight chest and light headed. I didn’t have anything for a couple of days and it wasn’t so bad so had a coffee today at 10am, it’s now 8pm and my heart is going mad, hot face as well. I’ve been drinking loads of water but just wondered if anyone on here had it or had any suggestions? Thanks in advance

16 Replies
KittyJ profile image

Not to be alarmist or anything Emle143 but if I were having palpitations, shortness of breath, lightheadedness and a tight chest for that amount of time I would get yourself checked out, even if you think you know the cause. For peace of mind. Let us know how you get on. I hope you’re soon feeling better🤗

Emle143 profile image
Emle143 in reply to KittyJ

Thanks, I have a routine blood test tomorrow so will see if I can get an emergency appointment to follow

HappykindaGal profile image

Have you had your BP tested? RA made mine soar and I was feeling like you are. I’d have that checked too.

Brushwork profile image

I would talk to your GP. I had some strange side effects from Sulfasalazine too, but mine were tingling all over, very weird.

It may or may not be the drug, so might be an idea to get it checked out.

TheBoys profile image


I stopped taking Sulfa when this happened to me

I took them in the morning and began to feel breathless/rapid heartbeat on the train on the way up to London where was supposed to meet some friends. I ended up booking into a hotel room to get myself when i got off the train I felt very woozy and dizzy. I went and lay down for a few hours. If it had carried on i d have gone to A&E.

I d stop them right away. Drink water and get rest. Check in with your GP if needs be.

Hi Emle143 anything to do with a tight chest racing heart and breathlessness should be checked out ASAP . Please do not delay . I do not mean to scare you but I would rather have it checked even if it turns out it’s nothing rather that than the alternative. Please do it and let us know how you get on.

Emle143 profile image

I ended up going to A&E after 111 recommended me to, they suggested I stay away from any caffeine or sugar until my next Rheumatology appointment on 18th Nov, hopefully they’re going to try and bring the appointment forward! Thank you for your advise

in reply to Emle143

Good luck let us know the outcome. Glad you went to A&E.

KittyJ profile image
KittyJ in reply to Emle143

I hope you are feeling better today ? x

Emle143 profile image
Emle143 in reply to KittyJ

Yes thank you, the GP told me to go back down to 3 tablets a day for a couple of weeks then up to 4 again. Having no coffee or sugar is proving quite difficult haha but powering through!

Whezziewhoozie profile image

Are you also on prednisolone? that could also be the cause

Emle143 profile image
Emle143 in reply to Whezziewhoozie

Yes, only down to 1 tablet a day now as it was only for a month. Luckily finishing them today actually so that might help

Whezziewhoozie profile image

i was on sulpha and prednisone, and had the same problem, once i reduced the steriods it seemed to help! Good luck

Mmrr profile image

I had a tight chest, cough and felt quite breathless on sulphasalazine. My rheumatologist stopped it claiming a salicylic acid allergy, which can become serious.

I think you need to seek medical advice.

(Initially I contacted my GP, who told me to increase the dose of sulphasalazine (!) Unhappy with that I contacted rheumatology who saw me and stopped it.)

Emle143 profile image

Hello everyone, I was also wondering if anyone else was having bad headache/migraines with these as well. I’ve been drinking loads of water but I seem to be going to bed with them and waking up with them? Struggling to focus at work, ibuprofen isn’t helping

Elmo333 profile image

Emle143 ... I definitely had terrible heart palpitations that would last for hours when I was taking sulphasalazine. It was horrible. They pretty stopped completely after I stopped the drug. It’s not a common side effect but it 100% happened to me. I occasionally have a palpitation but it was everyday when on SSZ. I would strongly recommend stopping it. Good luck

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