I have had to stop MTX after a couple of months due to severe headaches which were getting so bad that they were waking me up at night and I couldn't think straight. My nurse suggested stopping the Hydroxychloriquine first hoping that it was the culprit - no change. Stopped the MTX and the headaches went completely away after 5 days off. I'm now on Leflunomide (a week in) and so far, no headache, but I'm a bit concerned that it apparently takes a long time to work and I'm having a flare up now. I've re-started the Hydroxy. What have others experienced with it in terms of when it starts to kick in please?