Good morning. I have been taking methotrexate since December 2015. I can always tell when it's time for my next dose. I take it on Thursdays ( injections now). I feel great by Saturday and even better come Sunday. But by the time Tuesday and Wednesday come I start to feel crappy and tired. My hands will start to lock up on me. Does anyone else have the same problems. I feel the best I've felt in 4 yrs with this medication and I am doing things I haven't done in a long time because I have my mobility back. I was just wondering if it was me or if others have had the same experience with mtx.