I haven't posted anything for a while, but I have just had my 6 monthly rheumy appointment and after being on Hydroxychloroquine since May it was no longer working. Since i had my flare back in August/September due to stress my joints haven't been the same, my stiffness came back along with pain and tenderness. Some joints have gotten worse especially knees and my neck, (which my be osteo as i have had a bad neck for years, or may now be affected by rheumatoid who knows)! Anyway my rheumy gave me another intramuscular steroid injection and i have now just started on Sulfasalazine along with my Hydroxychloroquine. Since i have not had any xrays done for about a year and my Hydroxychloroquine didn't work i expected to have more xrays done just to check to see if there is now any damage, i just wanted to know how often does everyone else have xrays done, and is it done more often if you are seropositve? Also my rheumy requested more bloods including ESR and CRP, i asked her if she was going to test my rheumatoid factor to see if it has changed but she said there was no need as once you are negative you will always be negative! I was quite surprised by her comment as I am sure i have heard of people starting off as seronegative especially in the early stages and then changed to seropositve months or years later. Has anyone one on here gone from seronegative RF to seropositve RF? Also she reminded me how mild mine is, ok my joints don't blow up like balloons and i'm not deformed, but i still suffer with pain, tenderness, stiffness and fatigue! And without doing more xrays and rheumatoid factor how would she know if it is getting worse or not?! Sorry for the rant and going on a bit, i suppose i shouldn't moan, at least she has given me more medication, so she must be taking me seriously in some ways. Does anyone else with seronegative rheumatoid arthritis have the same problems?