I went back to my rheumy for my 6 month check this past Thursday. He asked how I was doing on the Hydroxy. I told him that I didn't see any real difference since I started taking it, and I have had constant diarrhoea and some nausea since starting it. He said that he still isn't sure that I have RA (I'm seronegative on every test they have run, except small erosions in my hands), and he just wanted to try the Hydroxy to see if it helped. He said since I was having an adverse reaction to the Hydroxy and if I didn't think it was helping he took me off of it. He wants to wait about 6 more months and redo x-rays to see if erosions have progressed, then if they have he will deem me seronegative and bump me up to a stronger medicine. I found that all acceptable and reasonable. Well fast forward 5 days and my hands are hurting SO much more than they had been. Could the Hydroxy have already gotten out of my system that fast, and maybe it really was helping me?? Does anyone have any experience with this? Thanks in advance!