I can almost (I say almost) put up with the pain but this constant tiredness is really getting me down. I was diagnosed 4 months ago. I am taking plaqunil, methatrexate injections 17.5mg soon to be 20mg, folic acid weekly and maloxicam 7.5mg twice daily as needed, started on sulfasalazine this week. I run a very busy 5 star B&B and have taken on more staff so that I can take on a more supervisory role. Sometimes I get up feeling tired and it goes on all day and sometimes it hits mid afternoon and I have go to bed. I know the drugs can take some months to work but will the tiredness get better as the drugs start to kick in?