Low EGFR with muscle mass: I'm a male 50 and... - Kidney Disease

Kidney Disease

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Low EGFR with muscle mass

Reegor profile image

I'm a male 50 and recently had blood tests with EGFR of 56. 2 other tests have 59 then 55. Going back through 10 years of results I've never been over 74. No symptoms. Had ultrasound on kidneys and perfect for shape, size, and blood flow.

Creatinine slightly high at 1.38. Rest of values are perfect. Non drinker health nut. Needless to say this freaked me out a bit.

After research, research and more research. (Remember kind of freaked out) I guess the EGFR is a calculation using age and other factors along with creatinine levels.

Creatinine levels can be higher in people with a lot of muscle from what I gather. Example: So if I'm 282lbs at 50 years old but my BF is 13% it means I have quite a bit of muscle and the EGFR may not be very accurate. I read I should actually be looking to get a Cystatin 3 Blood Test. It isn't as prone to false calculations with people with muscle mass or people that eat meat.

Anyone else come across a similar issue? Anyone with low EGFR but may have high muscle % and have this issue? Anyone get a Cystatin 3 blood test? Results?

3 Replies

Yes you are correct. If you think about creatinine in the same way as exhaust fumes from a car then even at tick over a 5 litre high performance engine is going to put out more waste products than a 1 litre engine. So yes if you have above average muscle mass then your creatinine is going to be naturally a lot higher than someone who has a small muscle mass.

Barbee44 profile image
Barbee44 in reply to rabbit01

So, I was a walker and biker for 10 yrs...I have a lot of muscle in my legs. I just had spinal surgery and now more bulging discs. I can't exercise.... could my GFR be low because I'm losing muscle mass?

rabbit01 profile image
rabbit01 in reply to Barbee44

I would not know the answer to that but certainly worth checking with your doctor.

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