I know it was just my 1st injection and I was so worried about the pain from more injections and the flu-like symptoms. I was on Avonex years ago and they were painful because I had to put the meds right into the muscle. I also have been on Lovenox shots so many times for my blood clotting disorder, those shots were extremely painful and bruised like heck from them. I took the advice I was given and took Ibuprofen before it was time for the shot. The nurse came out to teach me and I was nervous beyond words, I just wasn't looking forward to more painful injections. But great news, truthfully, when I gave myself the shot I never felt it, I pinched the skin after ckeaning with the alcohol pad and injected. Never felt anything, I thought maybe I did something wrong, the nurse was here and it showed the little dot, so yes I did it, and no flu like symtoms. Maybe as the dose increases it will change, but right now I am pleased. Thank you all for your wonderful support and advice.