In layman's terms

[Lynne-G]

Please could somebody explain the difference between Carl positive & Carl negative and what does the Carl mutation represent.I attach a picture from my porch..

Thank you 😊

[hunter5582]

There are three driver mutations that are the cause of MPNs. In order of frequency - Janus Kinase 2 (JAK2), Calreticulin (CALR), Myeloproliferative Leukemia virus oncogene (MPL). All three of these mutations occur in hematopoietic stem cells and cause the upregulation of the JAK-STAT pathway. In essence, the "on-switch" for blood cell production is always on.

When assessing for a MPN, it is now common to check for all three driver mutations. The CALR mutation can cause ET or MF or in exceedingly rare cases is reported with PV.

Here is an excellent and easy to understand presentation about MPN Molecular Biology.

youtube.com/watch?v=K5ZXdIw...(Not working as expected?)

[Lynne-G in reply to hunter5582]

Thank you Hunter. Really appreciate both your response & link Lynne.