Peginterferon

[caroline_284]

I'm wondering if anyone else is struggling with poor appetite while being o peginterferon.I have been on it for 4 years diagnosed with MF. The dose has gradually been raised but was then put up again to 135 weekly a few months ago because my spleen was enlarging.im now waiting for another appointment for an ultrasound,but am also feeling low with no appetite and being told to not lose weight!

[Exeter21]

Seems high weekly dose. Get a phone consultation with MPN for second opinion . 👍

[dbus1417]

It is possible your weight loss / low appetite is a result of your spleen becoming larger. It gives you a full sensation. It is a common thing to look for in MF.

[caroline_284 in reply to dbus1417]

Thankyou.im getting an ultrasound soon

[Bullace]

So sorry to hear you're feeling low and with no appetite. That's no fun at all. I've felt the same until they've got my dosage (of fedratinib) better balanced for me. I hope they find a better solution for you. Hilary

[caroline_284 in reply to Bullace]

Thankyou yes they are reducing my dosage

[Elizka]

I'm on Besremi and I haven't noticed a decrease in my appetite. Are you taking anything else that could impact your hunger? I recently lost weight due to a migraine medication. I'm making sure to drink a protein drink every day as I don't eat as much on this particular medication.

[caroline_284 in reply to Elizka]

I'm on other medications for high blood pressure too

[Elizka in reply to caroline_284]

Is that medication associated with weight loss?

[caroline_284 in reply to Elizka]

Peginterferon is but I don't think medicines for high blood pressure are.

[Pogm in reply to Elizka]

Hi,

Did your migraine develop as a result of Besremi? I had terrible headaches for 8 days after 7th dose of Besremi. I do have hypertension and my blood pressure increased as well. I upped my BP meds and the headaches have subsided, though there still remains an odd sensation in my head. Had a CT scan( normal) and MPN wants me to have a MRI "just to be on the safe side" as she quotes! I will continue Besremi but will go back to lowest dose (50mcg) and see how things go. I really don't want to give up on Besremi. My WBC, Hct and Hg are all in normal range now with platelets trending down. I also notice that I eat less on this med , as well.

[Elizka in reply to Pogm]

HI! No, I have had migraines since puberty. That said, they got worse for a short time on Besremi until I started Aimovig and Nurtec. CGRP Inhibitors. Combination of those drugs and more time on Besremi helped me. My Besremi dose is 150 and I would stay on it even if my migraines increased again as the benefits to me, are huge.

[Vtr1000]

Hi caroline_284, when my dose was increased to 90mcg per week my appetite initially shrank quite considerably to toddler portions to begin with. It took a few weeks for my appetite to increase slightly and it would vary as well. I am now on 45mcg every 3 weeks and my appetite has increased, but my appetite still varies.

[caroline_284 in reply to Vtr1000]

Thank you,that's helpful to know.I believe .MF itself can affect appetite.