« Treatment-free remission
Patients are considered to be in treatment-free remission when therapy is discontinued and the following occur:
Complete hematologic response
Deep molecular response
Reversion of bone marrow picture
Absence of vascular events and disease evolution
No treatment restart
Treatment discontinuation with interferon is feasible.
Prolonged complete hematologic response and <10% variant allele frequency at time of treatment stop is required »
Very nice abbreviated summary of treatment goals and strategies on MPN Hub. Thanks for posting.
7 ways to reach our goal! Way better that just one. Let’s’ Go team!! Thanks for the pep talk Manouche 🤼♂️🤼♂️🤼♂️ 🎉🎉🎉
On the MPN webinar with Dr. Prithviraj Bose yesterday, he started that there was no data to confirm that lowering the allele burden was related to disease progression, but there was a lot of discussion about this topic.
Interesting that this article has:
High allele burden is associated with an increased risk of myelofibrosis transformation
Event-free survival in patients with polycythemia vera treated with Besremi versus best available treatmentGreater Understanding of PV, ET Drives Potential New Treatment Options New hope to cure patients with MPNs
PV patients and Common Variable Immune Deficiency Adult Onset
Outburst of a young PV patient
