Interferon-Alpha 2-a and Its Dual Effect in Treating Two Diseases (Hepatitis C and Polycythemia Vera)

[Manouche]

 »Here, we report a 56-years-old male patient with hepatitis C virus infection and PV, who was treated with IFN for his chronic hepatitis C, which resulted in significant improvement of HB as well as normalization of his bone marrow and eradication of the clone (Jak2V617F).

…The patient received pegylated IFNα 2a in a dose of 180 mcg/week for 5 years. It took 2 years for the complete eradication of hepatitis C. He was cured of hepatitis c virus, and hemoglobin levels were normal (14–15.5 gm/dL), and repeated Jak2 v617f was negative. Bone marrow biopsy was done to evaluate for PV at the bone marrow level (panmyelosis). The bone marrow reported normal (no features suggestive of PV or other MPNs) »

karger.com/Article/FullText...

[hunter5582]

Very interesting and hopeful outcome. A rare case of two birds with one stone.

[Joetcalr]

interesting. I had hepatitis A 40 years before ET diagnosis. I’m wondering if it’s more common prior to getting an MPN, than in general population?

[Bluetop]

Oh that's a positive outcome!

[MAP44]

Thank you! Interesting read 🍻