Long-Term Use of Besremi in Polycythemia Vera: 5-Year Results from a Randomized Controlled Study and Its Extension

[Manouche]

« Patients with polycythemia vera (PV) require life-long treatment to prevent thromboembolic events and minimize the risk of progression. Ropeginterferon alpha-2b (BESREMi®; hereafter ropeg) may ultimately modify the natural history of PV by selectively targeting the malignant clone. In the PROUD-PV/CONTINUATION-PV studies, long-term treatment with ropeg was compared with standard cytoreductive therapy regarding thromboembolic and other adverse events as well as evolution of hematologic and molecular parameters over five years. »

ash.confex.com/ash/2020/web...

[Aldebaran25]

Thank you. Very encouraging 😊

[MPort]

Thanks for posting. This is encouraging. I wonder if those of us on Pegasys will be able to switch over?

[Manouche in reply to MPort]

They will, although some haems will be reluctant to do so if their patients are doing well under Pegasys.

[hunter5582]

More promising data for the use of Besremi. Besremi was mentioned in the recent MPN Advocacy Intl. Webinar with hope that it will be much easier for PV patients to access the drug once it is FDA approved for PV. Hopefully it will be so.

[ggrana]

Anyone know when it’s coming to the USA?

[BeHealthy1986 in reply to ggrana]

Hi Grace, I asked Dr Mauro this question last time. He said it is not approved yet. He also mentioned the ingredient is same as Pegasys but works longer with less side effects.

[ggrana in reply to BeHealthy1986]

I definitely want to try it I hope he agrees. I am pushing for it it sounds promising

[Aneliv9]

Is there any country that Besremi is already approved???

[Dovme in reply to Aneliv9]

Germany approved it and it has been in use since late 2019. I believe it has been approved by the EU as a whole and also some Asian countries

[Aneliv9 in reply to Dovme]

So here in Greece ( Europe) do we have Besremi approved for PV?

[Dovme in reply to Aneliv9]

Hi l think so as it was approved by the EU body for all 28 states plus Norway Iceland

aoporphan.com/po_en/our-com...

[saturn0325 in reply to Aneliv9]

Taiwan has approved it.

[MPNBlog]

Many thanks for posting this link Manouche.

[Maisie10]

Thank you for sharing