Covid treatments - Paxlovid or Monoclonals

[Emmyroos]

Well I guess it was bound to happen. The virus has finally arrived courtesy of my toddler and is taking us all down one at a time. What is the best treatment? Paxlovid or Monoclonals? Went to an urgent care today. They weren't sure whether I should have the monoclonal infusion or Paxlovid antivirals. They also said there may be some drug interaction between Paxlovid with Pegasys. My MPN specialist is out for the long holiday weekend (in the US) or she would be the first person I would consult and from my understanding I need to start something ASAP to be effective. So the next best to ask are my MPN friends. 😃 Anyone on Pegasys and take Paxlovid or Monoclonals?

[Barbiebreath]

I don’t have an answer for you but wishing you a speedy recovery! I’m going on 2 weeks with probable Covid now. Im not SO sick but can’t seem to totally shake it.

[Emmyroos in reply to Barbiebreath]

Thank you! And a full recovery to you also!

[hunter5582]

I checked on two sites and did not find any interactions between Paxlovid and Pegasys. I did get monoclonal antibody tx (Bamianivimab/Etesavimab) while on Pegasys. it was not a problem.

Perhaps someone is covering for your MPN Specialist if you have questions. You can also check with the Spoeciaisty pharmacy that provides the Pegasys. The pharmacists there can be very helpful.

Hope you feel better soon.

[Emmyroos in reply to hunter5582]

Thank you! Excellent idea about seeing my specialty pharmacist regarding drug interactions. Will contact them in the morning. Coming down with Covid on the Friday evening before a long holiday weekend is a bit inconvenient!

[SuET2017]

I don’t know for sure, but I am ET, take pegalated interferon and when I had covid in March I had sotrovimab 500mg infusion - I was fine on it. Hope you stay well

[Emmyroos in reply to SuET2017]

Thank you, Sue! Did it work well for you?

[SuET2017 in reply to Emmyroos]

Well, I wasn’t that unwell, just a sore throat, achy and tired. I probably had the omnicron variant, as that was prevalent at the time, so generally a covid with milder symptoms. The children had it at the same time, and also experienced milder symptoms. So whether it was the antivirals or just a milder variant anyway, I am not sure.

Still worth having the antivirals though, just in case. x

[Emmyroos in reply to SuET2017]

Agree that it would be worth it even if mild- - which mine is also so far.

[Orangeboykitty]

Paxlovid is known to cause symptom rebound (even Dr. Fauci experienced that) I would go for monoclonals or Ivermectin or Hydroxychloroquine, if you can get either of the latter two.

[Emmyroos in reply to Orangeboykitty]

I've heard of the possible paxlovid rebound - that is certainly not ideal. I appreciate your input. Stay well out there!

[charl17]

I will finish my Paxlovid in a few minutes. They took me off of tamsulosin but no one raised an issue about Pegasys. My guts are unhappy with Paxlovid so I'm happy to be done with it. Who knows if I got a benefit from this drug? Sometimes with a rare disease you have to trust the opinion of experts that know a little more than you do. We all will get Covid at some point.

[Emmyroos in reply to charl17]

I wish you a quick and full recovery. Thank you for sharing your experience. My husband is on paxlovid now too. He been describing the funny taste in his mouth. And I agree - it's just a matter of time for us all!

[Emmyroos]

I thought I would just follow up in case this information can help anyone in the future. My MPN specialist took time on her holiday to write me a script for Paxlovid. She recommended the low dose (150mg) Pax for me over the monoclonals available. I'm glad I got some meds as this mild Covid has turned on in the last 24hrs. I'm feeling kind of awful now. Thank you everyone for your input! Stay safe and be well !

[Devilgirl]

I had Paxlovid too - on Hydroxycarbamide - no rebound for me & although I had a metallic taste in my mouth so did my husband & he is otherwise healthy so no antivirals for him. I would therefore say the taste was a symptom of covid.

[Emmyroos in reply to Devilgirl]

I did not have the odd taste like my husband did or liss of taste/smell. It's crazy the different symptoms Covid can induce. I had virtually no side effects from paxlovid. Neither of us had a rebound (yet) either. Glad we're past Covid. It was no walk in the park for any of us at our house! Glad you are well!