Tired and itchy on Pegasys

[Sprat19]

Been on Peginterferon just over 2 months. Initially felt great and very energetic. The last 10 days I have been feeling rather energy lees and my skin is dry and itchy. Not very itchy just irritating. My last count 3 weeks ago showed my platelets had dropped but so had my neutrophils so my peg was reduced to 45 ug every 10 days

Unsure if my lethargy is Peg related or life. Same with my skin as I swim. Next appointment 13th so I guess I will see what my bloods show them. Must remember to drin plenty

[hunter5582]

Definitely stay hydrated. Very important with MPNs. Time will tell about whether what you are experiencing is a PEG reaction. You will have to monitor and see how it goes. I also have experienced the itchiness due to PEG and Besremi. I found that Claritin solved the problem.

Hope you get it sorted soon.

[R_Watson]

Hi, I’ve been on Peg for 6mths, currently on 180 weekly. Had the dry/itchy skin for a few months but that has eased off now, presumably as my body has got used to it so you may find that is relatively short lived. The tiredness/achey limbs is sticking around though and for me is the worst of the side effects because I am an active person normally. From what I can find staying well hydrated is the best advice, although I did also find a suggestion that moderate exercise can help…..if you don’t feel too tired to do it! I’m seeing my consultant this week and plan to ask him if I can do anything else to help with the tiredness so will add another post if he comes up with anything. Good luck.

[ainslie]

I have heard from a Peg veteran that Peg itself is dehydrating, also it can affect mood which can lead to lethargy, neither may be the cause of your issues but worth factoring in perhaps

[Sprat19]

Thanks all. I have upped the fluids. Took some piriton last night. That helped. . Need to find a non sedating antihistamine . I guess I will see how the week pas out and what the bloods show on Monday