Anyone had problems with elevated Liver function tests while taking Hydroxycarbamide…. Would be pleased to get some information ….

[Kilmichael]

ET mpl on Hydroxycarbamide 500 mgms daily …

[PhilReade]

Hi mine are always up my bilirubin and ALP and ALT all raised but Proffessor I’m under doesn’t seem worried

[Kilmichael in reply to PhilReade]

Thank you for that information … 🙏🏽

[tracey13 in reply to PhilReade]

My husband's liver function bloods were always high on hydroxy. He was sent to a liver specialist he said he had NASH liver non alcoholic related he did change his diet and that brought the numbers down a bit but it does say medication can cause LFTs to be high .

X

[Kilmichael in reply to tracey13]

Thank you all who replied on subject of Liver Function tests… Hope you are all keeping well ,

[hunter5582]

Hepatoxicity is one of the known toxicities associated with hydroxyurea. online.epocrates.com/drugs/...

drugs.com/monograph/hydroxy...

Monitoring liver function is one of the requirements for use of HU. Signs of significant liver impairment may require a change in your treatment plan. Fortunately there are other options should you not be able to tolerate HU.

[Kilmichael in reply to hunter5582]

Thank you Hunter, I was so worried … it is such a consolation to have such a knowledgeable person like yourself ,on this forum … 🙏🏽

[Virginia91]

Hi, I have fluctuating values in my blood tests concerning the liver. Yesterday my haematologist said she was going to consult with someone from the gastro.dept. She wondered if it could be caused by a gallstone.The values were also a bit high before I began with HU. I don't drink.

However they have been relatively high then the next month they were fairly ok.

sláinte

[Kilmichael in reply to Virginia91]

Thank you Virginia 91…

[tracey13 in reply to Virginia91]

Funny you should mention gallstones as my husband had emergency surgery last year to get his gallbladder removed .He went in hospital in absolutely agony they ended up sending him home 6 days later he was back in with sepsis and he had emergency surgery.

[Virginia91]

Hi, it's hard to know sometimes what is causing what. I hope your husband recovers soon. It sounds like it was an ordeal. All the best.

🙂