Just started taking Pegasys for myelofibrosis

[Emmyroos]

I'm 41 female, Jak 2+, prefibrotic MF. I recently started taking Pegasys. I'm 3 injections in. One of my main symptoms of the disease has been numbness in my hands and that seems to be much better immediately after starting. But now I have been having significant aching in my joints of my hands which I didn't have before. Does anyone know if this is a side effect of Pegasys or a symptom of the disease itself?

[hunter5582]

Aching joints (arthralgia) can be an adverse effect from the PEG. It can also be caused my the overproduction of inflammatory cytokines that results from dysregulation of the JAK-STAT pathway. If it did not start until after you began the PEG, then that would be a clue as to what the cause is.

Suggest you let your MPN care team know what you are experiencing.

Here is one reference on PEG AEs

online.epocrates.com/drugs/...

[Emmyroos in reply to hunter5582]

Thank you for the reply! I was hoping it was a SE of the Pegasys and not progression of this disease. Good info sent through also. Thank you!

[Goldie41]

I have the same diagnosis and my hem. dr. want to put me on 135 mcg Pegasys after 2 years of Hydroxyurea. What was your starting dose of Pegasys? Are you still on it?