Mutation

[ciye]

I have ET with mpl mutation but have no idea what that means

[socrates_8]

Hey there ciye...

Nice to be making your acquaintance. My name is Steve from Sydney, diagnosed 2016 w/ Post ET / MF (Myelofibrosis).

With MPNs ciye, there are basically Three (3) types of mutation known as the 'Driver' mutations. Those 3 ALL open the 'switch' for want of a better word to what is called the 'JAK-STAT' pathway, which in turn is what is thought as the major cause to the proliferation of our blood cells. Those three (3) Driver mutations are known as:

* JAK2V617F

* CALR

* MPL

There are a few other less well known or termed "Unclassified" Driver mutations but these are the main three (3)...

All I gather it means essentially, is that you currently have been diagnosed as having ET.

ET, essentially, is generally referred to as a chronic form of blood cancer that might prove entirely asymptomatic, aside from having elevated blood platelets. Here's a general link that might help explain a tad more for you:

mpn-mate.com/mpns-what-are-...

Hope this helps ...

Stay safe & well...

Steve

[ciye in reply to socrates_8]

Hello and thank you.