INF trial for early MF - impact of mutations

[Paul123456]

Not seen the full version before. Some interesting info albeit a couple of years old

onlinelibrary.wiley.com/doi...

I believe that Ropeg now approved for EU? Anyone know when it will become available?

[JohnSC]

Hi Paul,

BESREMi (Ropeginterferon) was granted marketing Authorization by the EU today the 21st February.

See aoporphan.at/news-medien/st...

I guess that AOP has now got to negotiate prices with the various national health services before it will become available. How long that will take is anyone’s guess.

[Paul123456]

Another more recent update re Peg v HU and Ropeg v HU

onclive.com/publications/mi...

[Bluetop]

Thanks for posting -now that Besremi has got European approval, I think it use will then be determined at national level and by each Trust

[AndyT]

My haematologist has told me it’s unlikely that Ropeginterferon will initially be approved for general use by most NHS trusts as it is massively more expensive than Pegasys, regular interferon and other treatments such as HU.

Given that many trusts won’t even approve Pegasys on cost grounds it sounds like Ropeginterferon could be an uphill struggle at first.

The situation might change in due course if Pegasys is discontinued by Roche due to declining sales in its original hepatitis field but my haem doesn’t think that’s likely to happen till the mid 2020’s.

It’s great that Ropeginterferon has been approved but we may be in for a long wait till those of us in the UK can access it on the NHS..!