MPN's anyone else have a raised red cell volume ?

[nightssky]

hi all just wondered any one else had a raised red cell volume along with the other usual raised counts ie white hemoglobin ,haemorcrit RD count etc

it's the RC- volume I'm concerned with would be interested to know if others have had this anomaly as well ?

[jointpain]

Raised MCV is normally associated with Pernicious Anemia. I have noticed my wife's MCV has gone up over the past four months in steps from 80 to 92.

[nightssky in reply to jointpain]

hello thanks for your reply that's interesting mine is 105 fl top of range is 101fl

[jointpain in reply to nightssky]

You should see your doctor and have your B12 serum level checked, also ask for your intrinsic factor to be checked. In the meantime do not take any B12 supplements or they will skew the results.

[nightssky in reply to jointpain]

hello & thanks for your reply very good advise I will ask doc cheers

[RobPV]

I'm by no means an expert but I think raises red cell count is a symptom of PV. I have PV myself. I was originally diagnosed with ET but after around a year my consultant noticed raised red blood cell count and changed my diagnosis to PV. I now have venesections every 6 to 8 weeks to keep rbc down. I hope this helps.

Rob.

[Ebot]

Yes. Goes with the territory!

[stillkicking]

Hi Nightssky,

You don't mention if you are on Hydroxyurea or other treatment. An upward trend in MCV can be the result of Hydroxyurea treatment, my MCV was 110 at my last test, and it has been working its way upward each month since beginning HU last January. I'll ask my hematologist about it on Wednesday when I see her, but I suspect that it won't be regarded as a thing to really worry about just yet.

Best Wishes,

Peter

[nightssky in reply to stillkicking]

hi I'm not on any treatment waiting for first appt with with haem so not sure about the red cell volume I also have raised red cell counts ,haemorcrit ,hemoglobin & white cells also doc referee me for PV ( suspected ) but was confused with the red cell volume ?

[stillkicking in reply to nightssky]

Hi nightssky,

I should have read your previous posts before I commented before and I would have seen that you weren't on medication as yet! Sorry about that! It will be an anxious time for you as you wait for your first appointment, and I certainly remember very well what all the waiting and uncertainty was like! I'm glad you found the forum at this point as you can ask questions and also pick up a lot of useful information through reading what others have said. It took me a few months to really accept what was going on with me after I was diagnosed, a process rather like grieving, and people here were very kind in encouraging me when I felt "down" or confused. Do make a list of questions that you have and take them to your appointment with your hematologist when that comes through.

Best Wishes,

Peter

[Sarah_786]

A raised MCV can be caused by b12 and folate deficiencies

[Bluetop]

My Mean Cell Volume is raised, averaging 110Fl, and I understood this was a result of the Hydroxy. Also Mean cell Hg (raised) and Mean cell Hg conc. -which varies. My red cells were slightly high on diagnosis (of PV) but have been controlled by the hydroxy., as has my haematocrit.