Hydroxycarbamide and platelets

[Kari1961]

Morning everyone.

I have PRV Jak 2 + and am due to start on hydroxy next month to control my HCT as it's always raised and regular venesections are causing low ferritin.

I read on here often that hydroxy is used to lower platelets in ET patients. However my platelet count ranges from 279 to 379 (normal) so in a case like mine would taking a drug used to lower platelets ultimately wipe mine out all together?

I'm just a worry wart! So I'm constantly thinking about and getting anxious that taking a drug could end up making me a lot worse off health wise.

[KevinJH]

I'd try not to worry too much. It's a fine balancing act that the medico's have to work out that'll suit you. I've been stable on hydroxy with platelet levels around the 190-240 mark for over six years. The v/section I'm having next Monday (draws breath, breaks into cold sweat then whispers a silent prayer......) is to help lower my HCT level. I mentioned that v/sections following diagnosis - PV JAK2+ - sent the platelet levels through the roof but he assured me not to worry as the hydroxy 'should' keep them at their current level. I'll let you know.....

[Kari1961 in reply to KevinJH]

Thanks for your reply and reassurance Kevin. I hold my 'normal' platelet level dear as it appears to be the one thing in my genetic makeup which has stayed strong and stable throughout my PRV journey...everything around it acts up and goes crazy! But my precious platelets hold firm and resolute. I'm just understandably worried about an increasingly wobbly bridge which I'm not looking forward to stepping on to.

I already take 5 meds daily due to PRV (my local pharmacist looks on my 5 as nothing)

Ramipril - high BP

Verapamil - irregular heart rhythm

Aspirin - blood thinning

Lansoprazole - due to taking aspirin

Cetirizine - for the dammed PRV itching (which don't work)

Now I'm on the cusp of adding another to the motley med crew... and I'm worried that it's going to add more complication rather than calm.

I'm keeping my fingers crossed that your venesection goes well.

[Wyebird]

Don’t worry 150 is the low end of normal. You’ve a long way to go. You will be monitored closely when you first start your meds.

[Kari1961 in reply to Wyebird]

Thank you Wyebird.