hydroxyurea can increase uric acid?

[Gringz_]

Its really frustating me, my gout seems to be worst when im taking up hydroxyurea, is there a connection with it, hydroxyurea increase my uric acid? Thanks

[jane13]

r u on allopurinol?

[Gringz_ in reply to jane13]

No, i only take hu

[AndyT]

How long have you been on HU..?

I’m on Pegasys but was given Allopurinol when starting treatment as platelet reduction can cause a gout flare up. Stopped it now as no gout symptoms once treatment was stabilised.

[Gringz_ in reply to AndyT]

Been two weeks now, i take hu 3x a day as prescribe by my doctor, i notice that i had a swelling foot cause by gout and my other joints is aching, is this because of hydroxyurea?

[Swede]

Yes! I suffer, now and then from gout. But when I do it is really really terrible. It ususally lasts for 6 weeks or so. Interesting thing is, when I spend time in warmer climate it does not happen......

[Gringz_ in reply to Swede]

What are your meds, hu and allopurinol?

[jane13]

as I understand it, if you have high levels of some cells such as reds it will cause/exacerbate gout, but you can reduce this by taking allopurinol. Don't think it is linked to hydroxy. sounds like u need to get some allopurinol asap?

[Gringz_ in reply to jane13]

Im taking allopurinol, cause my feet are aching like hell eversince i take hu

[Poppy112]

I take Allopurinol alongside interferon and have done since diagnosis, dose has been reduced over time but was told to stay on them until my platelet count reduces.

[Gringz_ in reply to Poppy112]

You take allopurinol and interferon in the same time or interval by hours?

[Poppy112 in reply to Gringz_]

I take my Interferon about 8-9pm and I take my allopurinol and Asprin around the same time.

[mjfin72]

Hi Gringz I have been on Allopurinal along with Hydrea since 19th Feb. Same as others said the Allopurinal is to try and control uric acid levels to prevent gout. I had been taking it in the morning with my aspirin but found I was feeling out of sorts during the day so take it now with Hydrea in the evening. Interesting you said how achy your feet have been since on Hydrea. Sore stiff feet and hands have been one of my symptoms for over 2 yrs but I have noticed a big increase in how sore my feet are since being on treatment. It feels like every bone hurts. I am on my feet all day for work which probably isnt helping but as I have been tested for gout and don't have it im assuming the achy feet is more to do with having ET or an autoimmune condition which I'm waiting to be investigated for.

Hope Allopurinal gives you some relief. From what I hear gout can be incredibly painful.

Take care

Mandy

[Gringz_ in reply to mjfin72]

Thanks for the advice

[Juliet46]

Hello I have been prescribed allopurinol since the day I started hydroxycarbamide to prevent gout.

[Gringz_ in reply to Juliet46]

Im taking allopurinol, thanks

[stillkicking]

I understand that there is a link to being on Hydroxy and gout, and, had I not been on allopurinol already when I recently started Hydroxy, my haematologist would have prescribed it. What I have read somewhere is that an excess of uric acid is released because so many platelets are being killed off when on hydroxy.

[Gringz_ in reply to stillkicking]

My platelets is raging in 1500, im taking HU 3x a day and my feet really hurts of gout

[stillkicking in reply to Gringz_]

You certainly are having a horrible time, gout really hurts!

When you were first given allopurinol, did your doctor prescribe an anti inflammatory drug for you? When I started allopurinol, my GP gave me a course of anti inflammatory pills. She said that if I was put on allopurinol without them then allopurinol could cause a flare up of gout because it messes with the level of uric acid, and it would take time for the body to adjust to things. I had to be on the anti inflammatory medication for about 2 weeks, then was able to go off it and just stay on the allopurinol. I am not a doctor, so I can't really give medical advice, but I am wondering if you need to be on a course of anti inflammatory medication to treat the gout itself. The allopurinol simply lowers the amount of uric acid in the blood, and makes it less likely that you will get gout, but if you have gout already you will need something to clear that up. Anti inflammatory medication is sometimes used for this, another effective medicine that is used for gout is colchicine. Your doctor would have to work out what was safe for you to take with your Hydroxy.

I do hope you are able to get help with this really soon.

Best Wishes,

Peter

[Twinkly]

It affected my gut badly too ..I'm now on ruxulitnib it's by far better for me .iv been o,k, for nearly 4 years ,,. But I eat really healthy fresh only diet ,no alcohole or canned drinks especially coke cola ... Cook fresh every day veg ,fish ,chicken . It takes a while but the body re adjusts ,. Then you feel fresh again ...hope this helps you ... Twinkly . Xxxxxx