I'm beginning to really think about the relationship between depression and fatigue and the extent to which one impacts on the other. It's never really discussed except in general terms and then often only in relation to specific drugs. Has anyone come across any studies on fatigue, depression and MPNs / cancer or the effects of anti-depressants on fatigue? If you're debilitated and frustrated by your condition is it any surprise we can feel depressed? And if we then feel depressed is it any wonder that we feel more fatigued and debilitated? I think this is one I may have to confront! It would be helpful to see the wood for the trees.