After a year of Pegasys and steadily reducing platelets my last 3 counts have started to creep up again to 320, 380 and now just over 390. Still in normal range but I suspect I'll be back over 400 by the end of the year. Not too concerned as I guess the answer will be to increase the frequency of injections from every 4 weeks to every 3 but it's a bit disappointing as my consultant had suggested we might extend to 6 weeks if my counts had stayed stable. Anyone else had experience of Pegasys or regular interferon becoming less effective over time..?
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