Here I am newly diagnosed with ETand also tested positive for Jak2 and trying to decide when to start the HU. I am rather afraid of this drug and wondered if others have experienced hair loss, weight gain etc., etc., I am 64 so I fall into the criteria of a risk for stroke or heart attack so my haemo told me. I questioned him as my platelets are 700 now slowly rising from 640 last year. My symptoms are bruising and tiredness. I am guessing I have had this for a while as I kept noticing blood spots under my skin over the past few years actually and everyone just said it was thinning skin! I am not overweight, blood pressure normal, so wondered if that would make me less risk for stroke as it seems they just put you into a certain criteria without checking other areas. My haemo phoned me to discuss this and he said I fit the criteria, yet he has never met me or seen me so doesnt know if I am normal weight etc., etc., confused totally.