Tarceva Side Effects and dosage reduction - Lung Cancer Support

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Tarceva Side Effects and dosage reduction

cammfam4 profile image
7 Replies

Hi there, I wanted to ask this group about stepping down the MG's of Tarceva to alleviate some of the symptoms. I am currently on 150 mg daily for the last 3 months and have so many issues, hair loss, the big D( almost daily) , extremely dry flaky skin, runny nose with sores, loss of appetite, nausea etc. pretty much everything but the face rash which I did have in the beginning but luckily that went away. I have read some people have down sized and done fine, I am a small person and don't weigh much so I'm thinking maybe 150mg is too much for me? Dr. wants me to stay on for as long as I can tolerate the higher dose, but its getting pretty hard dealing with all these issues on a daily basis. My husband is worried that I will jeopardize my treatment since the drug is keeping things in control, but my quality of life with all these symptoms makes me want to do something about it if I can. If you reduce the dosage does it change how well it can work for you and how long you can stay on it??

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scifiknitter profile image
scifiknitterBlogger

Cammfamm4,

Dose reductions are common with Tarceva. At a conference I went to last fall, I learned that 1) the dose has been set at a maximum dose that was tolerated by the majority of patients, and not based on minimum effective dose, and 2) lower doses are usually as effective in sensitive patients.

I agree that the side effects can be more challenging than others think, and that your interest in a dose reduction is reasonable.

Anita

cammfam4 profile image
cammfam4 in reply to scifiknitter

Thank you, I will check with my Dr. Take care,

njane27 profile image
njane27

I also am a small person and had trouble with 150 mgs. I've been taking 125 for about 9 months with much less side effects. Praying for many years with this treatment. God bless.

cammfam4 profile image
cammfam4 in reply to njane27

thats good to hear, thank you!

Diamajoy profile image
Diamajoy

I also was on 150 mg of tarceva and was miserable. I did reduce to 100 mg. I tolerated it as long as I could but my quality of life was miserable. Finished w radiation and now on new drug tagrisso after mutation.

Esthersm profile image
Esthersm

I have been on Tarceva since 4/2012 on 150 mg for 3 years then continue 100mg until now. I use cetaphil cream for the dryness of the skin. At the beginning the itchiness just drove me insane, I made oatmeal , ( make a big pot " used the water to put in the bath as well as "oil" . Also I use cortisone cream or oilment 2.5 mg for the "rash or pimples" on the face & scalp. But the Tarceva keeps me almost 5 yrs alive. I use soap made from olive oil, only use to clean areas that I need too, but the shower just wash my flaky skin away & keep me clean & refresh, put on Cetaphil from face to toes. I also use argon oil serum for my hair after " head & shoulder" shampoo. That's the only thing I can use because of the itchiness & rash on the scalp .also my hair becomes very dried & curly. I had been on Cyberknife for my brain . If I can do it You can stay on it . It all depends on the scans & your progress to determine to reduce the dosage. Just deal with the side effects one at a time .Good luck to you!,

cammfam4 profile image
cammfam4 in reply to Esthersm

Thanks, I have scans in March so I will have to tough it out until then.

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