Haemochromatosis/immune system

[craftyguru]

does anyone know whether haemachromatosis affects the immune system.

[BeezyB]

Not sure but would say no, not directly anyway. However all your system affected so one could say indirectly suppose?

[radd]

craftyguru,

Welcome to our forum.

Long term elevated iron levels can have a detrimental effect on our immune system.

From what I read research seems to indicate that the immunological problems are more likely with HH (mutated HFE gene) which is the most common cause of Haemochromotosis.

.

Effects of Iron Overload On The Immune System.

annclinlabsci.org/content/3...

[Fennella02]

Hi. I'm new on here and not strictly entitled to be here as I don't have hemachromatosis but some form of iron overload. My main condition is Lupus and, in answer to your question, I absolutely do think that iron affects the immune system in susceptible people. It causes my lupus to flare every time i take the tablets to bring my HB up. Iron infusions give me Type 3 hypersensitivities. I get classic signs of iron overload (malaise/crippling fatigue/arthritis in certain finger joints and muscle/.joint pain in others) despite having a low HB and low ferritin - apparently it is possible albeit unusual.