A review of repurposed drugs

[Maxone73]

Clinical trials which evaluated some repurposed drugs

ncbi.nlm.nih.gov/pmc/articl...

[NPfisherman]

Max,

At some point, a strategy to utilize repurposed drugs makes total sense, especially in regards to treating other medical issues. An article on repurposing for Pca:

ncbi.nlm.nih.gov/pmc/articl...

There number of drugs will increase over time.... Each person should look at their disease, and the genetics behind it, to arrive at possible candidates. Individualized (Targeted) therapy is the future of oncological research.

Don Pescado

[Maxone73 in reply to NPfisherman]

I agree with that. Serendipity happened in science since forever and AI is making things faster and faster.

I just prefer to have some clinical study behind those decisions, because quite frankly, in vitro and on mice basically everything works. If I had the immune system of a rat I would not even be on this site probably

Not only, it's not just a matter of blocking this pathway and that pathway, it's that there are also conflictual supplements, where one cancels the effect of the other, or amplifies it too much (one clinical study found that vit D3 promotes cancer when it is below a given level but also above a given level...that's why I love being in the middle with that ).

Then there is gene over/under expression, I have posted something before the holiday, where researchers at a university hereby at las discovered that is not under expression but over expression (or viceversa) of a given gene (I don't remember which) that causes cancer, and only now they know how to use it as target...

If I cannot have one reliable big (possibly publicly funded) clinical trial, let's say I point my nose where the majority of smaller trials are guiding me.

[NPfisherman in reply to Maxone73]

Agreed....getting a Phase III trial with results takes too long (if at all)....like you, I look at the results of Phase II or multiple Phase IIs, and use that as my guide..

It was why I chose to do SBRT for my oligometastatic disease, despite one poster saying over and over there is no proof of benefit.... I loooked at the initial SABR COMET, and realized there was a good indicator.... Since then, we have had ORIOLE, POPSTAR, ARTO, etc that proved there was benefit--prolonged time to ADT, PFS, improved QoL, etc...

For me, I am more interested in the core issues that can cause cancer to accelerate... like cholesterol and inflammation...