Oncolytic-virus-therapy

[Scout4answers]

This looks like another promising avenue to a potential cure.

cancerresearch.org/treatmen...

[cujoe]

Scout, Thanks for trying to get us back to the reasons we should be spending time here - sharing info and patient experience.

Somewhat less than 150 years ago, William Coley laid the groundwork for today's field of Immunotherapy. In his case, he induced fevers in cancer patients by infecting them with known viruses. The fevers apparently resulted in a ramp in the immune system that caused it to it find and destroy cancer cells otherwise untouched.

It has now only taken most of the interim 100+ years for medical science to pick up on his insights. More recently the NIH's Dr. Steven Rosenberg (National Cancer Institute, Center for Cancer Research) is credited with the first successes with Checkpoint-Inhibitors. Unfortunately, for those of us with solid tumors, Immunotherapies have yet to show much benefit for the mainstream patient community. However, as in all such advanced science, our hope for better treatment outcomes continues to spring eternal.

Here is a profile of the history of Immunotherapyfrom Coley to the time of its publication in 2020. The Section 4.4, Oncolytic Virotherapy, discusses the approach used in your post.

Talkin’ Toxins: From Coley’s to Modern Cancer Immunotherapy, Toxins (Basel). 2020 Apr.

ncbi.nlm.nih.gov/pmc/articl...

Keep S&W, Ciao - Capt K9

[Spyder54 in reply to cujoe]

thanks Cujoe. Nice history lesson on Immuno therapy, tying in nicely with Scouts piece. These make me feel we are getting closer. Mike

[Spyder54]

Thanks Scout. Immuno therapy is probably in our future. Provenge, as we previously discussed, has the ability to extend life. Not yet a cure.

The idea of injecting a virus that could be attached to PCa cells with a PSMA Ligand is intriguing. I keep remembering the microscopic video of white blood cells clustered around PCa cells, but not attacking, as if confused, and not recognizing the enemy. This Virus therapy would have the ability to penetrate the PSMA shell around the PCa cell, infect the PCa cell, thereby alerting the surrounding WBC’s to attack, and do what they are supposed to do. Kill these invaders.

Mike

[Scout4answers]

Thanks for the positive thoughts

Microdiscectomy perform by Dr. Phillips. He pioneered it back in the '90s and teaches others at Rush medical center in Chicago. I have Drop Foot caused by a pinched nerve at L 4-5. Recovery numbers are less than 50% so I need my extraordinary luck to kick in.