NonMetastatic Castrate resistant

[JolleySprings]

What is the difference in the treatment of Metastatic disease and Nonmetastic Castrate Resistant disease? Is one easier to treat than the other?

Thank you!

[cujoe]

Jolley, In general, we can say that, irrespective of CR status, non-metastatic disease is potentially curable, while metastatic cancer (using currently available treatments) is not.

Looking at your profile, I see you were seeking to be a patient of Dr. Antonarakis at U of MN. If so, with the CDK-12 genetic defect you were in good hands. Here is a very detailed paper he first-authored on CDK-12 from 2020 that you should review, if you have not already.

CDK12-Altered Prostate Cancer: Clinical Features and Therapeutic Outcomes to Standard Systemic Therapies, Poly (ADP-Ribose) Polymerase Inhibitors, and PD-1 Inhibitors

ascopubs.org/doi/full/10.12...

Finally, as with all cancer treatments, the location, extent, and genetic profile (at least partly available in your case) will determine the type of treatment for best efficacy. In thinking about that, this zoom Prostate Education Series- Dr. Charles Ryan and Dr. Alicia Morgans also from 2020 might help you understand the range of treatment options available. (You might want to skip ahead to about 40 mins in, as the first portion covers topics related to diagnostics that you should already be familiar with.)

Prostate Education Series- Dr. Charles Ryan and Dr. Alicia Morgans

youtube.com/watch?v=T5878gU...(Not working as expected?)

Also covered at the end of this video is emerging PSMA theranostics, so here is a paper that reviews the use of PSMA for treatment as well as a diagnostic tool.

PSMA Theranostics: Current Landscape and Future Outlook - Cancers (Basel). 2021 Aug; 13

ncbi.nlm.nih.gov/pmc/articl...

There can be little doubt that the more you know, the better you can partner with your MO/RO in directing a treatment plan. Knowledge is power in this case and your husband's longevity and QOL depend on it. May you formulate the best treatment plan and get an excellent outcome.

Ciao - Capt'n K9

[NPfisherman]

JS,

Agree with the K9... Reviewed your posts...Your MO is knowledgeable about your CDK-12 mutation. I know tango gave you information on clinical trials. See the MO, and let him provide you with the best options and make a decision..

Attached an article on developments in CDK inhibition:

ncbi.nlm.nih.gov/pmc/articl...

Wishing you the best...

Don Pescado