Reducing the side-effects of prostate... - Fight Prostate Ca...

Fight Prostate Cancer

2,910 members1,175 posts

Reducing the side-effects of prostate hormone therapy with exercise - New report from the other side of the pond

cujoe profile image
22 Replies

We all know and are constantly reminded that exercise is key to combating the side effects of ADT. Well here is some recent clinical evidence to support it. From the study report:

"This is the first study to assess whether the effects of supervised exercise in prostate cancer patients beginning ADT can be maintained after the withdrawal of supervision. The 3-month aerobic and resistance training intervention prevented adverse changes in cardiorespiratory fitness and fatigue. After the supervised exercise was withdrawn, differences in cardiorespiratory fitness and fatigue were not sustained, but the exercise group showed higher QoL and a reduced cardiovascular event risk compared to the control group. These findings have important implications for clinicians concerned with the management of ADT-related side-effects."

The bottom line is that the exercise helps, but once supervision is withdrawn it seems the self-directed exercise was less rigorous and therefore less effective.

NOTE: There are several similar research efforts cited in the paper that those on ADT might also want to review.

From ScienceDaily:

sciencedaily.com/releases/2...

And the whole paper PDF download:

sci-hub.tw/10.1111/bju.14922

Winning by doing! Be Well - K9's bedtime

Written by
cujoe profile image
cujoe
To view profiles and participate in discussions please or .
Read more about...
22 Replies
cesanon profile image
cesanon

Dr. Myers emphasized that the resistance training was especially important. It actually interacted with the hormones.

NPfisherman profile image
NPfisherman

Thanks for posting this information, K9 Terror...

Like my post about getting moving after Thanksgiving...Exercise increases longevity as well as helping with the ADT S.E's... I try and hit the gym about 4x a week... Good stuff... I also have been reading info about the benefits of the steam room/ sauna for muscle aches:

medicalnewstoday.com/articl...

Saw another article somewhere about immune system benefits...will try and respond with it tomorrow...

Fish

marnieg46 profile image
marnieg46 in reply toNPfisherman

I've seen clear evidence NP for myself of what a difference a specially designed exercise program, targeted for men on hormones, can make. It made the world of difference for my husband once he started Lupron. He went from being totally (and I mean really totally inactive) to looking forward to his twice weekly gym sessions. While he will in normal circumstance look for any excuse to avoid movement there was no way he'd miss the gym. His fitness improved and also the side effects of Lupron have been minimal ....perhaps as a result who knows. It was also an emotional boost and he was also pleased with himself as he could do more and more challenging activities and would discuss these with a great sense of pride.

One benefit that can't be quantified, is that by engaging in a specific program, he seemed to feel for the first time in a very long time, that he could do something to help himself and he had control over what was happening rather than just being passive and wondering what was the next piece of bad news he was going to receive.

For him the Man Plan offered by the manufacturer of Lupron has been a blessing. It is something that he would do now even if it is not subsidised in the future.

Unfortunately he's not able to go to the gym until a health condition is rectified and only yesterday he said with some sadness that he has one regret and that is he can't go to the gym and might not be able to go for sometime. He also sees some of the benefits slipping away. However, in my opinion, even that he recognises the importance of being active is a great move forward and something that he might have known intellectually before the program but chose not to put it into action.

So all in all I totally agree with the posts in this thread about the benefits of exercise and for my husband the research quoted in cuJoe's post certainly reflected our experience including the QOL findings. Always good to be reminded of those simple things that can be done to help along the journey.

cujoe profile image
cujoe in reply tomarnieg46

Marnie,

Lot of people here are hoping for a resolution to hubby's 'health condition' in early 2020.

Been there myself, so I appreciate that his issues can and do restrict an active lifestyle. He'll eventually get back to it. Best Regards to You Both - Be Well - cujoe

marnieg46 profile image
marnieg46 in reply tocujoe

Yes a resolution would be good and I'm sure everything will work out well and he'll be back to the gym and his mates there in no time at all.

There has been a bit of mirth from our girls though about the procedure and a fair bit of squirming from our son....so it's also brought a bit of humour into the situation which is good. One daughter suggested he could be the new act in a performance at Vegas that her husband recently took part in to which Ron replied that if he does they shouldn't sit in the front row!

You too be well... m

NPfisherman profile image
NPfisherman in reply tomarnieg46

What cujoe said...LOL..

Hoping for resolution to his issues and back in the gym...weight lifting, even light weights with multiple reps helps maintain bone mass.....a concern with ADT...

Have a great week...

Fish the NP

marnieg46 profile image
marnieg46 in reply toNPfisherman

Yes a resolution will be great. He does say Fish that he doesn't think he'll be allowed to get back on the bike at the gym but the weights will be good. You too have a good week.... 😊

cujoe profile image
cujoe in reply tomarnieg46

Yes, bikes and horse-riding are out, so there goes Ron's dream of the Tour de France and the Kentucky Derby. (Altho' I was told I could bike with a special seat.) But being able to "vacate at the press of button" really is priceless. 2020 will be a dry year down under in the land of Oz. Be Well - K9

marnieg46 profile image
marnieg46 in reply tocujoe

Ron smiled at your posting! He says it might be an interesting sight at the urinal! He wonders if he could sell tickets?

cujoe profile image
cujoe in reply tomarnieg46

Everybody on these cancer forums needs to cultivate a good sense of humor. Your relayed comments from Ron make me think he has definitely not lost his. Hopefully he'll have lots to laugh about in 2020. Be Well - chewJoe

addicted2cycling profile image
addicted2cycling in reply tocujoe

Why do you think I had a Bilateral Orchiectomy ??? ---- Instead of ADT effects the Orchi lightened my load and made my BICYCLE RIDING MORE ENJOYABLE!!!!!

Bicycled a quick 41 miles this morning just to stretch the legs after Saturday's 177 miles.

NPfisherman profile image
NPfisherman in reply tomarnieg46

I am wondering if bringing a Spenco seat cover--lots of extra padding would make a difference for getting back on the gym bike... just a thought...

Fish

cujoe profile image
cujoe in reply toNPfisherman

The one my surgeon described sounded like one of these??

ismseat.com/comfort-saddles/

Early this year, I started using a recumbent bike at the gym, thinking it would not cause any problems. But after 15-20 mins 2-3 x per week on the bike, I noticed I was having some non-stress related leakage. And while minor, it did seem that it might be related to my bike work.

It was while sitting on the bike one day that I realized that even on a recumbent bike, there was pressure on the cuff. Since "erosion" at the cuff is one of the major causes of device failure, I immediately dropped the bike from my exercise program. Within 30 days after stopping the bike workouts, things were back to "my normal". There are lots of other ways to get aerobic exercise, so no reason to risk an early failure with biking.

Note: For those lost in this discourse, we are taking about the artificial urinary sphincter; i.e., the implanted device that allow incontinent patients to regain their urinary control and "pee at the press of a button". (More accurately, squeeze of a bulb.)

Be Well - cujoe

NPfisherman profile image
NPfisherman in reply tocujoe

I had something like this made by a company called Spenco--worked good...

ebay.com/itm/Silicone-Gel-E...

Gel....easy on my tush...

Fish

dougnola profile image
dougnola

I’m a believer first-hand but it’s nice to see it in peer-review. In February, I’ll have my next bone-density scan so it’ll be interesting to see if my rate of bone loss continues to decline due to this sort of exercise regime. Thanks Cujoe!

cujoe profile image
cujoe

8 Mile Doug,

I seem to remember that your MO has you on Calcium supplements? Did you ever run the suggestion to add Magnesium, K2, and Boron to the Calcium? Jus' wundrin' . . . BTW, Dem Saints look to be Marchin' & Breesin' their way to Super Sunday. Keep Moving & Be Well - cujoe

NPfisherman profile image
NPfisherman

Okay, so here we go on the steam room:

healthline.com/health/steam...

I like it post workout....jacks up the core temperature...I like to take a canister of Boost oxygen in and breathe that for a minute or two when I get nice and toasty...

Don Pescado

cujoe profile image
cujoe in reply toNPfisherman

Seems about right to me. You do need to try the eucalyptus oil drops on the corner of the wash cloth over the steam outlet. Really refreshing and maybe even therapeutic? or not . . .

today.duke.edu/2018/05/smel...

Be Well - cujoe

NPfisherman profile image
NPfisherman in reply tocujoe

I read the Duke Today article and the "meatier" article also, and while they identified agonists for the olfactory receptor OR51E2, I did not see antagonists for the olfactory receptor... They did state the following in the real meat...:

Aromatase is increased 30-fold in metastatic PC (59), and aromatase-knockout mice have a reduced incidence of PC following exposure to testosterone and estrogen, indicating that aromatase metabolites, mainly 19-OH AD and estradiol, are likely involved in prostate carcinogenesis.

Maybe that is one of the reasons why Nalakrats does so well....Aromatase Inhibitor...

Fish

cujoe profile image
cujoe in reply toNPfisherman

Any comment, Nalakrats. We are waiting with fish-baited breaths.

BTW, howz the weather in the Sunshine State?? And are the real fish biting yet?

Be Well - Captain K9

NPfisherman profile image
NPfisherman in reply tocujoe

So I reviewed essential oils and I would go with boswellia serrata oil or lavender oil...see below:

callmeoil.com/best-essentia...

Anyone have any other ideas...

Fish

cujoe profile image
cujoe in reply toNPfisherman

I'm out of time, but you've spurred my interest. I'll get back to you later. cujoe

Not what you're looking for?

You may also like...

EXTEND - Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic Prostate Cancer

The results of the EXTEND [EXTernal beam radiation to Eliminate Nominal metastatic Disease] Phase...
pjoshea13 profile image

Making a Case for Intermittent ADT in Metastatic Hormone Sensitive Prostate Cancer

FPC'ers, Many times, we hear people claim that you should only stop ADT if you can't tolerate it...
NPfisherman profile image

The 2024 Advanced Prostate Cancer Consensus Conference (APCCC) meeting-- Chock full of Testosterone...

Greetings FPC Forum Dwellers, Marnie passed me some solid information on the APCCC...and it is all...
NPfisherman profile image

Long-Term Adverse Effects and Complications After Prostate Cancer Treatment - JAMA Oncology, Nov 7, 2024 - w/ SWOG commentary

A very important baseline study for those considering treatment options. This paper would have been...
cujoe profile image

The Existence of the Oligometastatic State in Prostate Cancer (and other cancers)

Members of the FPC Forum: I submit to you that either I am a Prophet/Visionary, or I am a Fool,...
NPfisherman profile image