Hello everyone, I have been suffering from MPN for over 10 years, although I am very young. JAK2v617F. Due to misdiagnosis in the beginning few years, that cause my spleen volume was huge. When the diagnosis was made, the doctors all exclaimed that I had already faced severe anemia, but I'm not. Now I'm taking Rux.
But what I am worried about is the failure of molecular genetics. I have ASXL1 mutation, and am currently moving towards MDS. Bone marrow biopsy has shown that there are sick megakaryocyte, although my fibrosis has been reversed.
Do you have any strategies for this? I am afraid of transplantation because there is no donor in my family and I still need to support my parents.
🙏Thanks!
Written by
merlisa
To view profiles and participate in discussions please or .
But this needs a qualified institution like MDAnderson here to search for suitable donors.
--
Recent advance have improved outcomes and unmatched donors are even possible with the latest methods.
"Recent advances in GVHD prophylaxis and donor selection have reignited interest in MMUD (mismatched unrelated) as a feasible and suitable option for patients without a matched donor "
From my limited understanding, in addition to genetic mutations, age is a big factor in the overall outcome of the HCTs. If you're young, with the recent advances in donor matching technology, it is highly plausible to qualify even with a half-matched donor. Have you discussed your transplant options with your team?
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.
