resmetirom

[Maxy6]

Anyone on it? What side effects have you experienced? Any results?

[johnsonk13]

Yes, I have been taking this new drug since May 2024. My Fibroscan results from January 2024 to September 2024 are amazing the positive change from taking this medication. I highly recommend it if you can get on it. I am tired sometimes but I'm not sure that this can be attributed to this medication. Good Luck!

[Maxy6 in reply to johnsonk13]

Thanks so much for your answer. I don't see my hepatologist again until late February but I am hopeful of getting a prescription for it. We discussed it briefly before my liver biopsy. Do you have fibrosis?

[PistachioPlease in reply to johnsonk13]

Just started, 5 days, no side effects yet and way to early for results.

[PistachioPlease in reply to PistachioPlease]

Maybe some slight nausea, but not much. Two weeks in.

[Deborahkd22]

I asked my new Dr at the U of Mn if she would prescribe it for me (stage 2)…She said “no” and suggested they are more excited about a drug not yet released. She suggested starting a glp1 (I’m struggling with weight loss but not horribly overweight or a diabetic) … surprised! My gen dr also would not prescribe it for me, which is why I decided to treat with a liver dr/dept. disappointing especially when you hear about others doing so well with it. So glad to hear that it is effective for those who are getting it!!

[Maxy6 in reply to Deborahkd22]

There is some research that shows that some GLP-1 and SGLT2 meds help with MASH. I have been doing a lot of research.

[Tarzan01 in reply to Maxy6]

I heard that GLP's side affects include digestive issues. Is this true?

[Maxy6 in reply to Tarzan01]

Yes but that is also a side effect of the liver meds too. In my particular case, I also have neuroendocrine cancer and some thyroid nodules, so they may not be a good idea. My biopsy showed stage 3 fibrosis but haven't seen hepatologist back yet.Interestingly, fat was F0-F1.Our bodies are weird.

[Tarzan01 in reply to Maxy6]

I hope things get better for all of us. Yea, my doctor told me that glp can cause constipation and could get dangerous if a person doesn't drink a lot of water.

[NYLassie in reply to Maxy6]

My liver enzymes have vastly improved since I have been on Mounjaro. They had improved before that when my regular doctor added Zetia to my medications. The Zetia combined with Crestor was doing a lot of good, but with Mounjaro, it is next level. I stopped seeing my hepatologist because he is so focused on research. If I don't participate in a clinical trial, his attitude is, oh well, you and your liver are on your own. I miss my 1st hepatologist who retired.

[Deborahkd22]

I’ve read that,too and it makes sense because weight loss is essential to turning this disease around. Thx Maxy

[kidsdogs4me]

I've been on it for 3 months and my levels have stabilized. Hopefully a few more months and they will begin to drop. I have tried to adjust my diet also, but it's very hard. I've also done tons of research on the the GLPs and I had a prescription, but my insurance would not cover it. My issues are all genetic with a long family history of cirrhosis.

Table

[kidsdogs4me in reply to kidsdogs4me]

Liver values

Table

[Maxy6 in reply to kidsdogs4me]

I have never had abnormal labs but biopsy showed stage 3 fibrosis. I think mine may be from a clotting disorder. Can't wait to D/W Hepatolgist.

[kidsdogs4me in reply to Maxy6]

My levels have been increasing for many years and I finally had a biopsy a year or so ago and my liver was worse than labs had shown. Mine is all genetic so hard to fight that, but in trying.

[Tarzan01 in reply to kidsdogs4me]

Looks like things are improving. Keep doing what you're doing

[kidsdogs4me in reply to Tarzan01]

At least there's hope!

[Cats2018]

Hi, I was in clinical trials for Resmetirom for 2 years. The 1st year I don’t know if I was on Resmetirom or a placebo but then Madrigal guaranteed I would be on the drug if I consented for another year of the trial. I took the 80mg for the 1st 3 months and the 100mg for the remaining 9 months. I didn’t have any problems with it. My FibroScan results were improved at the end of the trial. I was off Resmetirom for about a year and a half while waiting for FDA to approve it. I was happy to be able to get back on it after FDA approval March 2024. I was able to get back on it (now called Rezdiffra) In July 2024 & my FibroScan October has already shown improvement in my CAP score. I hope you can get on it.

[DataLiver]

been on it since July 2024. Saw scan improvements but not labs just in last two weeks started to feel worse again, started itching and bloating/nausea. Entire time on the Rezdiffra I have felt abdominal discomfort and a lot more tired. Also makes my excretions smell very odd, like ai am sweating out the excess lipids or something else.