F3 to F4

[BB273]

Diagnosed 1-12 yrs ago with F3 fibrosis. Now up to F4. They used Fibrotest-Actitest both times to diagnose stage of fibrosis. I seen mentions on here of numerous diagnostic instruments, but not Fibrotest-Actitest. Does any have any information/experience with this? Any info about the validity/reliability of this instrument?

[BB273]

That should say 1-1/2 years ago, not 1-12.

[nash2 Partner]

It is marketed in the US as Fibrosure but is the same blood test

en.wikipedia.org/wiki/Fibro....

[MINTVCX]

Check this, it is about "Non-invasive assessment of liver fibrosis"

"The Fibrotest® (Fibrosure® in the USA) is the most widely validated indirect serum marker panel (...) It is computed using five parameters, namely total bilirubin, haptoglobin, gamma-glutamyl-transpeptidase, a2-macroglobulin and apolipoprotein-A. In a systematic review including 9 studies (1679 patients), an excellent discrimination was found for identifying cirrhosis (summary AUROC=0.90), but a lesser ability to identify significant (≥F2) fibrosis (AUROC=0.81)."

" Similarly, interpretation of the Fibrotest results should be done critically taking into account that hemolysis (decrease in haptoglobin), Gilbert’s syndrome (increase in bilirubin) or inflammatory states (increase in α2-macroglobulin) can be associated with erroneous results."

ncbi.nlm.nih.gov/pmc/articl...