Recent Research Result: α-synuclein may o... - Cure Parkinson's

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Recent Research Result: α-synuclein may originate from the kidney and spread to the brain.

jeffreyn profile image
11 Replies

"These observations suggest that eliminating circulating α-synuclein may be a possible way to halt the progression of PD."

MedicalXpress article. The link between renal failure and Parkinson's disease: Researchers illuminate the underlying mechanisms.

medicalxpress.com/news/2025...

Research paper. Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson’s disease.

nature.com/articles/s41593-...

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jeffreyn profile image
jeffreyn
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JayPwP profile image
JayPwP

Thanks 😊

So the gut is acquitted from all charges? What about the vague nerve?

jeffreyn profile image
jeffreyn in reply toJayPwP

All roads lead to Rome. (maybe)

Kruidje profile image
Kruidje in reply toJayPwP

The gut is responsable for what happens in the kidney's. If the gut does not function well, the kidney has to work harder. But actualy what we put in the air we breath and what we put in our mouth and what touches our skin will role how are bodys work. All the organs work together if we put to much work on one, over time the other organs will suffer to.

MarionP profile image
MarionP

And those who have no renal problems? What about people who have been exposed to chemicals that cause Parkinson's?

LAJ12345 profile image
LAJ12345 in reply toMarionP

My guess is the α-synuclein is a protective slime the body produces to wrap toxins of all kinds to protect cells and to mark as waste for the body to dispose of.

Nobel prize please😅

jeffreyn profile image
jeffreyn

A road less travelled (MSA).

VAI article: Study links bladder inflammation from UTIs with development of multiple system atrophy.

vai.org/article/study-links...

realk profile image
realk

I think this connection - brain and kidneys is nothing new.. Chinese medicine is working with it thousands years already.

Chillla profile image
Chillla in reply torealk

Several years before I was actually diagnosed with Parkinson's in 2014, I went to a Chinese man, doctor, and he said I had cold kidneys. He gave me a bunch of herbs to take and left it at that. I didn't notice any difference but then again I probably gave it only a half-hearted effort. I never did figure out what cold kidneys meant but maybe there's some relationship here.

Kruidje profile image
Kruidje in reply toChillla

Cold kidney's could be due to cold drinks, raw foods (fruit and vegies, yoghurt), or cold enviroment or cold plants (some plants cool one down, some heat one). Like bananas and spinach are very cooling. Also nuts and seedoils are cooling. It is importent to eat coocked meals 3times a day. Except red meat.

Red meat and fats from meat you can eat at roomtemperature, it is neutral. Some herbs heat your outside like pepper and chili, but they burn the kidneys. You need herbs that warm from they inside out.

Gioc profile image
Gioc

interesting jeffreyn , but in my opinion from the same website, even more interesting this research:

Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles”

medicalxpress.com/news/2024...

pnas.org/doi/10.1073/pnas.2...

michelagvolpe profile image
michelagvolpe

α-synuclein is everywhere!

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