Which one is the most promising ongoing trial for PD

[Farooqji]

In my opinion Stem Cell Trials

what others think?

[Memento_mori]

NNI-362 seems pretty interesting. Also Buntanetap.

[Obiora]

GBase related drugs

[peminc]

I keep an eye on ANVS, IKT & also looking forward to learning the results of the Phase 2 Orchestra trial of UCB0599 from UCB & Novartis.

BlueRock makes my list

[chrislind2016 in reply to peminc]

December 2024, UCB announced that UCB0599 did not meet the primary and secondary clinical endpoints in the ORCHESTRA trial, failing to demonstrate improvement in Parkinson's symptoms compared to placebo. Consequently, UCB and Novartis decided to discontinue the development of UCB0599.

[peminc in reply to chrislind2016]

Yikes!

[PDKiwi]

Broccoli Seed Tea, Frequency Specific Microcurrent and DMSO and DMSO-like compounds.

[karter1 in reply to PDKiwi]

Do you know what frequency this suggested with microcurrent? I am currently doing this therapy through a Health and Wellness center, and I would love to have more information on specific frequencies. Thanks for any help you can provide!

[PDKiwi in reply to karter1]

I don't know the frequencies sorry but Dr McMakin will know as she references in her book, helping a South Korean man with PD. I would imagine that therapists share this information however here in NZ they are few and far between.

[Gisel]

Happy New Year! 4 weeks ago I had a therapy with mesenchymal stem cells that had been extracted by a special enzyme from my aspirated belly fat tissue and partly reinfused i.v. and partly injected into the nose the same day. Success rate is expected to be 85% in neurological diseases such as Parkinson´s. It was not easy because I am very slim but they managed to find enough fat tissue. During the procedure I was anesthezised with Propofol. I have been told that it can take 3 - 4 months till I can feel a positive effect. Up to now I managed to reduce my L-Dopa/Benserazid (100/25) from 5 to 3 tablets/day and reduce my Pramipexol from 1.57 mg to 1.05 mg. I was diagnosed 3/2018. I am thinking that if there is an ongoing inflammatory process in the brain as one reason of the disease, I should find out how to stop it in order to avoid a negative influence on the stem cells that are expected to convert into neural cells.

I do not think that there will be one specific cure for Parkinson´s in the future, instead I expect a combination of different compounds with different mode of action to be successful similar to the complex treatment of some type of cancer. My belief: A complex disease needs a complex treatment.

[peminc in reply to Gisel]

Keep us posted. Fascinating!

[Gisel in reply to peminc]

will keep you posted !

[Patient100 in reply to Gisel]

Gisel, where did you get your stem cell transplant done? And what was the cost? Hope you experience improvements in your condition over the next few months and tell us about them. Thanks.

[Gisel in reply to Patient100]

Dear patient100 I had the stem cell therapy done in Munich, Germany. Costs 10,000 €. Will keep you posted!

[JJRunt in reply to Gisel]

Gisel I’m intrigued - where did you get this done?

[Gisel in reply to JJRunt]

Dear JJRunt, I had the stem cell therapy done in Munich, Germany. Will keep you posted!

[Gallaktika in reply to Gisel]

and where did you undergo treatment?Thanks

[DIY4PD-GBA]

Ambroxol is starting a Phase 3 trial in the UK. Ambroxol is available in much of the world as generic, OTC cough medicine! and is just being repurposed now for PD.