One final cautionary note before we finish: Despite all the excitement surrounding NRF2, it is important to remember that too much of a good thing can be bad.
Continuous activation of NRF2 can be pro-tumourigenic – that is, it can encourage the growth of cancerous tumours. Cancer cells generate a lot of oxidative stress, which usually helps to kill off the cancer or at least keep the growth under control. Sometimes somatic (or spontaneous) genetic mutations can occur in the NRF2 gene which results in hyperactivity of NRF2 and it continuously activates target genes. These target genes help to reduce the oxidative stress in the cancer cells, which in turns helps to keep those cells alive and multiplying. Thus, one must be careful with over activating NRF2.
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What is needed is a study to assess how much sulfurophane is safe. In the meantime this is a real risk of unknown size. While we are on the subject of carcinogenic supplements, it is very important to be aware of this:
Very foolish. You would discount probably all the most prescribed PD drugs and at least 20,000 CTs, studies, and articles available on PubMed. Newer is not always better.
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What caused my Parkinson's
alpha synuclein, amylin, chatgpt
Parkinson's Research, Is It Destined to Follow the Same Fraudulent Path as Cancer Research?
