Distribution of phosphorylated alpha-synuclein in non-diseased brain implicates olfactory bulb mitral cells in synucleinopathy pathogenesis
Bryan A Killinger 1, Gabriela Mercado 2, Solji Choi 3, Tyler Tittle 3, Yaping Chu 4, Patrik Brundin 2 5, Jeffrey H Kordower 4
March, 2023
pubmed.ncbi.nlm.nih.gov/369...
nature.com/articles/s41531-...
"Discussion
The OB has been hypothesized to be one potential starting point for alpha-synuclein pathology and, thus the synucleinopathy disease process1,11. This contention is supported by several observations, including (1) mitral cell loss in PD OB2,5,18,32, (2) high incidence of LP in synucleinopathy OB3,5,33,34,35, and (3) incidental LP in OB3. Our inadvertent observation of PSER129 (which is usually associated with disease) in healthy mitral cells seems to support this hypothesis. "
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