New Study on Inulin

[pdpatient]

Nothing is going to be the long term solution to anything. I posted an article on Inulin earlier that had great promise. Now, this :

news.weill.cornell.edu/news...

[Bolt_Upright]

Great find. I like this "These unexpected discoveries may help explain why high-fiber diets often exacerbate inflammatory bowel disease in patients". I have had something like IBS my whole adult life and never got any relief from a high fiber diet (quite the opposite, actually).

Thanks!

[chartist]

This is a rodent study, vs the human study I linked to which showed anti inflammatory effects plus increased SCFA production, which is also shown in humans with PD to increase anti inflammatory effects and generally improve the gut microbiome :

ncbi.nlm.nih.gov/pmc/articl...

I am discussing inulin in terms of people with PD and I would place those results well ahead of a rodent study that doesn't appear to apply to people with PD. Why would you compare a rodent study to an actual human study utilizing inulin in people with PD???

Art

[pdpatient in reply to chartist]

Well, Art, I hope you are correct. I am sitting on a 2 pound pack of inulin. I would hate to waste that.😂

I do understand that we need to take all this with a grain of salt or inulin. Lol.

[JayPwP in reply to pdpatient]

😆😆😆

Don't sit for too long lest the Inulin may hatch...

[chartist in reply to pdpatient]

I'm still taking it without problem. I would think that if it were always inflammatory in humans, I would know about it by now, but so far, have only noticed decreased inflammation.

Art

[alexask in reply to chartist]

Is Inulin the new Mannitol? Seems pretty similar. I still rate Mannitol.

[chartist in reply to alexask]

Inulin just has a growing body of evidence that continues to confirm its health related effects in humans and specific health conditions that make it worthy of consideration for those that have a health condition that it may help, such as myself.

Art

[7springshollow]

Thank you for posting this. I started taking inulin and after that exhibited IBS symptoms..

[Zella23]

it definitely helps my husband with constipation issues.

[Trig27]

The studies I have seen in rodents that have caused inflammatory responses were proof of concept type studies where the rodents were eating vast quantities of inulin. On the order of 30% of all food was inulin. That's a lot.

Here is a nice paper what inulin consumption used to be, before it was added to packaged foods or available as powder:

sciencedirect.com/science/a...

I seriously doubt that small amounts (a few grams) of supplementary inulin will cause an allergic/inflammatory response. I would also be surprised if 30% of your food consumption was one kind of fiber you didn't have an inflammatory response and generally feel miserable.

Eat a diverse group of vegetables. If you supplement with fiber use a mix of fibers.

[Rufous2 in reply to Trig27]

There are also different types of inulin, and any individual one could have beneficial effects (or not) depending on one's microbiome composition. For instance, those with a high burden of desulfovibrio might benefit more from inulin derived from agave, rather than the more common chicory derived form;  sciencedirect.com/science/a...

"Agave inulin differs from other inulin type fibers in chemical structure and botanical origin. Preclinical animal research suggests these differences affect bacterial utilization and physiologic outcomes."

"Desulfovibrio were depleted 40% with agave inulin compared with control."

I agree that diversifying fiber intake (with an emphasis on resistant starch) is probably beneficial. At least one small study suggests this; ncbi.nlm.nih.gov/pmc/articl...

"All fibers promoted SCFA production with fiber-specific effects noted for each SCFA. Resistant maltodextrin and inulin produced the greatest increase in total SCFA levels followed by resistant starch and rice bran (Fig. 2b and Supplementary Table S1). Each fiber type had a distinct metabolic signature: resistant starch was highly butyrogenic, resistant maltodextrin was highly propiogenic, and inulin and rice bran promoted the production of all three SCFA."