Stem cell 101

[gomelgo]

This could be a good resource for anyone considering this approach. So I figured I would share it here. I got it from a lecture I attended. Claire Henchcliffe shared about her work in this field, and she shared this resource. Hope it is informative for others.

summitforstemcell.org/stem-...

[JayPwP]

Thank you for sharing 🙏

[SAGoodman]

Really informative information, thanks for the 101!

[kaypeeoh]

Interesting. But this is a brain disease forum and author says stem cells don't work on the brain. I dunno. In my veterinary practice I saw fat cells transform into fibrous tissue and heal torn ACLs. Mesenchymal cells would have to be able to cross the blood brain barrier. For MS, abnormal cells are crossing the BBB and damaging myelin sheaths. Tysabri is a monoclonal antibody that stops that process by binding to the abnormal cells before they can cross. I read a study on fat cells being 1000% better than marrow cells. I collected fat and injected the stifles (knees) of large dogs with torn ACLs. Then I tried collecting more cells for personal use. But something went wrong with my 50 yr old centrifuge and it made an unholy mess that took days to clean. And I never got around injecting myself. But I'd like to think that someone is trying to get mesenchymal cells to cross.

[gomelgo]

The author of this is not talking about any specific purpose, just giving general information. Claire Henchcliffe who shared it with those of us on her session, was also surpprised to learn about Hope Biosciences and that they are working on infusion of cells rather than surgery.

[NextStage]

From the referenced document:

Are there other uses for stem cells?

We’ve already discussed how stem cells can be used for cell therapy but stem cells have many other uses, some of which will be important for Parkinson’s and other neurological diseases.

Disease Modeling – Stem cells, and in particular iPSCs, made from someone with a particular disease show hallmarks of that disease when the cells are differentiated into the cell type affected by the disease. For example, it is well-established that people with Parkinson’s disease show an abnormal accumulation of α-synuclein in their brain. iPSCs derived from Parkinson’s patients that are differentiated to dopaminergic neurons also produce abnormally large amounts of α-synuclein. What this means is that stem cells can be used as an infinite source of diseased cells that accurately reproduce the disease in a dish. From there, these cells can be used to screen for drugs that correct problems associated with that particular disease. Currently, iPSCs and hESCs are widely used in drug screening to find treatments for Parkinson’s and other neurological diseases.

If I am reading the above correctly, and what it is saying is correct, then we should NOT expect good results when the stem cells are made from our own body? It seems like more people should be talking about this. . .

[gomelgo]

wow! Thank you so much for pointing us out. This is definitely a concern that I have had and others have raised. We all need to be talking about this for sure.

[JohnPepper]

Why go to the expense and danger of surgery , when all you have to do is walk as fast as you can for up to one hour, every second day! Thousands have done it and have succeeded. Why mess around with medications that don't work or any other unsuccessful method?

Walk as fast as you can, for up to one hour, every second day. It costs nothing and it is the only successful way of reversing PD.

I was diagnosed in 1992 and since 1996 I have lived a normal life. I am now 89 and still look forward to many more years of activity.

[gomelgo in reply to JohnPepper]

John I would love to hear from others who have followed your method.

[Alock2020]

This looks very interesting, but it hasn't been rated yet by charitynavigator.org/discov...

[gomelgo in reply to Alock2020]

What hasn't?