Diet and the gut microbiome in patients with Parkinson’s disease

[Farooqji]

nature.com/articles/s41531-...

[Obiora]

Thank you Farooqji you do a great work with all the info yo bring to the forum, keep it up!

[Zella23]

Thanks for posting this research, it’s really interesting and supports the importance of diet effecting the gut brain axis.

[LAJ12345]

”In this study, we observed that a better diet (indicated by a higher HEI score and fiber intake) in PD patients was associated with an increase in SCFA-producing bacteria, including Butyricicoccus, Coprococcus 1, Hydrogenoanaerobacterium, Negativibacillus, Romboutsia, Ruminococcaceae NK4A214 group, and Ruminococcaceae UCG-003. These SCFA-producing bacteria, primarily known for producing butyrate, provide energy for intestinal epithelial cells, strengthen the intestinal epithelium, and reduce inflammation22. Moreover, the anti-inflammatory properties of SCFAs affect the enteric nervous system, promote normal microglia development, and potentially modulate inflammation in the central nervous system23.

On the flip side, a higher intake of added sugar in our study participants led to a decrease in Butyricicoccus, Coprococcus 1, and Romboutsia. In PD patients, a lower abundance of SCFA-producing bacteria has been found in a series of studies in comparison to healthy controls9,10,11,12,13. PD patients have higher levels of pro-inflammatory cytokines in the colon and serum, suggesting that they suffer from systemic inflammation, which could result in microglial activation that drives disease progression24. For instance, a lower abundance of Butyricicoccus was noted in patients with early PD and REM sleep behavior disorder10, and a lower abundance of Romboutsia was associated with worsening cognitive function and depressive symptoms in PD patients25.”

[LorenzaS]

I am considering Fecal Matter transplant !

[JayPwP in reply to LorenzaS]

DIY?

[LorenzaS in reply to JayPwP]

Actually in Europe there are some private clinics that provide this treatment in Denmark or in Slovenia . DIY also possible, there are capsules for sale. 😅😂

[JayPwP in reply to LorenzaS]

I am going to try my child's poop some day

[LorenzaS in reply to JayPwP]

good luck with that!

[Mellaji in reply to LorenzaS]

Where have you considered going?

[LorenzaS in reply to Mellaji]

I have contacted a clinic in Bratislava that does it. It is quite expensive . You can google it FMT Bratislava