indiamart.com/proddetail/bu...
the Molecular Formula:C20H23N3O2 are the same
I wonder if Annovis phase III turns to be successful the stock still available
Buntanetap from indiamart: indiamart.com... - Cure Parkinson's
Buntanetap from indiamart
Written by
limcheeese22
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56 Replies
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Wow, that's $12 a kilogram.
Too good to be true
Hi Bolt, how did you get the price? I contacted the sellers IndiaMart suggested, but no feedback. Thanks, Laura
It says on the page: Buntanetap CAS 116839-68-0, For Pharmaceutical Industry, 500gm bottle ₹ 987/ Kg
987 Indian Rupee equals 11.85 United States Dollar
but i chat with them they quote me 1xxx per 10g, other than indian mart, the market price is minimum 2xxxx per 10g!!!
They should know. Don't know how you could be sure it is the real thing. Not sure if the trial results are out yet.
Annovis has delayed the PD trial result for close to 3 months...
not a good sign
oh, I see😂 thanks a lot!
Not so sure i would 100% trust Indiamart with my life
Why not?
If only there were an affordable way to measure purity of drugs from Indiamart. You never know what these resellers are cutting with the product they send you.
Exactly, and even if there were I'd want to check each batch for consistency
Mass spectrometry
In 2016 I went in on a group buy of Nilotinib and we used this to verify the drug was what we wanted
thermofisher.com/us/en/home....
Interesting! What was the cost? How did the results compare to what was advertised in Indiamart? And the results of the meds?
We didn't get the stuff from Indiamart. We found a compounding pharmacy to make it. It was molecularly identical. The drug was dirt cheap (as I recall 10 cents/gram,) so the testing was an affordable part of the total cost.
I do not believe mass spectrometry can determine whether the sample is the (+) enantiomer of Buntanetap that is active and desirable, but I suppose also you would need to test the polarization of light. These tests are not cheap and please just wait. Hard to do but do no harm.
do you have links to support that?
Do you do so for every supplement you take or is this curiosity reserved only for IndiaMart?
i got this email from Indiamart.
"NCI was established in 1982 in Mumbai, India. We manufacture inorganic chemicals like Nitrates, Sulphates, Alums, Carbonates, and Tartrates which are used in a variety of industries including veterinary medicines, electroplating, oral hygiene, pharmaceuticals, and agriculture fertilizers among others. We take great pride in our product quality and have been working with top MNCs for years. We export to more than 21+ countries including the UK, Brazil, Slovakia, Thailand, China, South Africa, Bangladesh, UAE, Japan & the USA.
We are ISO 9001:2015, ISO 22000, HACCP, WHO-GMP, REACH registered, FSSAI, FDA Approved, Kosher/ Halal-certified & Ecovadis-approved company."
Thank you Marc 🙏
Big whoop, that's just standard marketing materials. Of course that is the standard thing to say. What else would one say to promote one's business? A bad actor is going to say the exact same thing, obviously. Saying a thing doesn't make a thing true. Does the hunter say 'oh this arrow is dangerous to you my deer'? Does the fisherman offer a fish an unhookedfly for dinner, or display the hook under the fly? What's the purpose of the fly? It's not even a real insect, that's very intention is still fool and deceive prey so the prey can be caught. So that's no way to tell anything. The crook uses the same good sales pitch, sometimes better, than the honest man... And even the honest one can be fooled in doing business getting materials accepting claims that their sources are good and the exact same way. Whoever actually calls ISO and ask them about the applicant? And how good is ISO in the first place? And even applicants who passed their ISO levels, don't make mistakes? Thought about getting on a Boeing aircraft lately? There needs to be a testing and MB Anderson is absolutely brilliant for pointing that out and also maybe showing us how to get it done.
you can get it tested with consumerslab
I am not looking to test the products.The question raised by the members is about the quality of the product because it is of Indian origin.
Is the same diligence applied to other supplements by the said members? For example Vitacost B1, which is of Chinese origin?
Two wrongs don't make a right and two fools don't add up to smart. It's gambling admit it, but don't defend it because other people rush in, it's still gambling. You either want to be informed or you don't. Either you give a crap about something or your consonant about taking the risk. Plenty of people will do fine, and then there are also plenty of people who uttered "famous last words" and thought it wouldn't apply to them, until it did: "Step on her boy, you're only doing 75. We can beat the train to the crossing easy. Hey man there's only one bullet in a chamber, all the other chambers are empty." Four out of five times maybe you will be okay. But which one do you avoid, and does that match what might happen?
Quite a few reports about recent recalls of poisoned OTC meds from the four largest US distributors of their own private label eye drops, contaminated by bacteria some cases of which included complete loss of eyes including the eyeballs, and some deaths ( at least two deaths). We are talking Walmart, we're talking CVS... A sharp eyed pharmacist and another sharp eyed doctor identified that they all had one thing in common, made in India. Current recall, I repeat, current.
Consider this link, one of many available on the subject:
thehill.com/policy/healthca....
But that's okay Jay, you go right ahead. Only you can decide what makes sense for you. Which reminds me of saying I was once given by a mentor in the 1970s (I've been saying that a lot lately, wonder if it means I'm too old for this stuff anymore): "People will rarely 'understand,' so don't bother trying to explain."
You make a good point about China, anything coming from China should be tested also. Although I understand that's where we get all the best fentanyl via the Mexican drug cartels, it's sourced in China.
they haven't published the results from the most recent trial yet have they?
Not that I have seen. Buzz is the delay does not increase the likelihood there is much good news 
Its very interesting. Should we take risk of testing it on ourselves without waiting for the phase 3 results? a big question
If I could get my hands on some before phase 3, I'd take it. I was in the trial and felt some benefit. It relieved me of constipation after 3 months.
Well at least you actually have a basis for judging something and also for people judging what you have to say, and that's a good thing. I don't think many others can say that. Everybody else here is blowing smoke up something or out of something. But on the other hand, things being manufactured in India, including contractors doing pharmaceuticals and pharmaceutical components under license and then assembled and packaged and marketed by others, have quite a deserved reputation. A decent standard might be would you do this to somebody you love?
my.indiamart.com/enquiry/me...
Yes I'm sure if they're doing anything improper they are certain to let you know if you contact their customer service people.
statnews.com/2024/02/23/ann...
need subscription?
yes, but the important thing is concentrated in the title
We should keep in mind the results of any study do not apply to everyone in the study equally. A study that does not meet its end points (for the majority) may be of significant benefit to a minority of the cohort.
True dat.
Please tread carefully: sitejabber.com/reviews/indi...
even if Indian Mart Was highly rated and purchased buntanetap was considered quality by mas spec, how would you know dosage and really do we have any idea of mechanism of action to understand if it is more valuable then easily accessible drugs like ambroxal or exenitide that may be disease modifying. Id love to hear any thoughts?
i am taking ambroxal for more than 6 months, no effect
I've been taking exentide for over a year and have had considerable improvement in tremor but the bradykinesia continues to progress
I you mean $4K/g, that's way, way too much.
As I remember the doses in the trial were 10 mg and 20 mg, bringing the cost/dose to $40 & $80 per.
I dont trust anything made in Chinese, India or other third world county labs. It's one thing if you are talking about grinding up leaves from the ginko tree but another when making a fully synthetic molecule. But if it makes you feel better I don't 100% trust unregulated supplements made in the US either, so maybe i'm just paranoid.
Dietary Supplements as Source of Unintentional Doping
"Results: The total number of analyzed Dietary Supplements is 3132, 875 of which were found to contain undeclared substances. Most frequently found undeclared substances are sibutramine and anabolic-androgenic steroids."
"Conclusion: More than 28% of the analyzed dietary supplements pose a potential risk of unintentional doping. "
pubmed.ncbi.nlm.nih.gov/354...
Marc,
Is there a source country differentiation for the 3132 supplements which were tested?
No, unfortunately not.
"Materials and methods: Literature search was done through PubMed, Science Direct, Google Scholar, and Web of Science. Studies investigating the presence of undeclared compounds, in dietary supplements, banned by WADA (World Anti Doping Agency) met the inclusion criteria. The last search was conducted in June 2021. The present review is based on a total of 50 studies, which investigated the presence of undeclared compounds in DS."
from Examine.com
"One of the most comprehensive papers on this topic was a 2022 review of 50 studies. More than 3,000 supplements were analyzed, sourced from all over the world, including the U.S., the U.K., Italy, Germany, and China. The findings were concerning, to say the least."
Thank you 🙏
Very good, bravo.
Quite a few reports about recent recalls of poisoned OTC meds from the four largest US distributors of their own private label eye drops, contaminated by bacteria some cases of which included complete loss of eyes including the eyeballs, and some deaths ( at least two deaths). We are talking Walmart, we're talking CVS... A sharp eyed pharmacist and another sharp eyed doctor identified that they all had one thing in common, made in India. Current recall, I repeat, current.
thehill.com/policy/healthca....
But that's okay fellas you go right ahead.
Yeah you're just paranoid. And Lord knows when someone is paranoid, then what they're worried about can't possibly be of concern, except by gross coincidence. I'm sure the FDA was wrong about all of these different brands and generic brands all coming from India it's probably not important and probably irrelevant.
even the trial turn out to be super good even the source turn out to be reliable (lots of other sources) but I don’t think we are affordable to have it due to the cost. At least 50 - 60 per dose. I think most likely the price on Indiamart is not correct.
I wonder what is the price will be if Annovis to market it, will they able to bring down the price
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