Biomarker Found

[pdpatient]

Parkinson's Biomarker Found?

michaeljfox.org/news/breaki...

[jimcaster]

I'm probably missing something, but I don't see it as that big of a breakthrough. We already knew of the association between Parkinson's disease and alpha synuclein. We still don't know whether alpha synuclein build up is the cause or an effect of Parkinson's disease. I guess it's nice that it can be measured in living humans but unless it's definitively determined to be the CAUSE of Parkinson's all the treatments to remove it may be a waste of time. Correlation does not equal causation.

[MarionP in reply to jimcaster]

Ditto, for proper early warning they can contact me about 30 years ago. But minus the spinal tap!

[chartist]

That was discussed on this forum last April when the news release was given after a week of buildup about a major PD breakthrough coming from MJFF! I notice that they conveniently forgot to mention the required spinal tap in their release article. It was a big nothing then and is a big nothing now. Laurie Mischley's dogs seem as or more accurate , less costly and does not require a spinal tap or an office visit. I wonder how much MJFF contributed to the funding for that research? Simply put, a year later and no mention of that major PD breakthrough anymore.

Art

[Boscoejean in reply to chartist]

yes with skin tests and blood tests being developed why would someone want to have a spinal tap

ox.ac.uk/news/2023-12-05-re....

The Syn-One (Skin Biopsy) Test

The Syn-One Test® is a pathological test that uses a skin sample to confirm the presence of phosphorylation in nerves, which can carry the protein that plays an essential role in Parkinson’s. Test results can help PD doctors confirm a Parkinson’s diagnosis.

For this test, your neurologist, or another physician, will perform three small skin biopsies on the upper back, lower thigh and lower leg. The areas are numbed with a local anesthetic. Results take about two to three weeks to be delivered to your doctor.

[chartist in reply to Boscoejean]

I'd rather do that than a spinal tap, but mostly I would just send my dirty t-shirt to Dr. Laurie's dogs! I like dogs!

Maybe MJFF should ask for a refund of their funding for that breakthrough other thing!🙃

Art

[MarionP in reply to chartist]

I agree way better. I didn't know you could do that, send your shirt to the dogs?

[chartist in reply to MarionP]

youtu.be/wgbgxP2s2HU?si=uzu...(Not working as expected?)

Art

[LAJ12345 in reply to chartist]

I’ll sniff them for you. I can smell it.

[Rupa88 in reply to chartist]

MJFF always disappoints me

Big organization, a lot of employees, lots of show offs and nothing fruitful😥😥

Ugggggghhhhhhhhhhh

[WinnieThePoo in reply to Rupa88]

That's more likely to be because you understand nothing about scientific and medical research, never mind the specifics of parkinson's disease, than because what you say is true

[Rupa88 in reply to WinnieThePoo]

I am sorry but FYI

I am a physician and a researcher and do not agree with organizations way of working just because the head person has PD or is a celebrity.

Corruption is corruption

In any shape and figure

[LAJ12345 in reply to chartist]

This article is from last April so not new

[crewmanwhite]

Such a waste of research money. Even when detected, we won't know whether that person will develop PD, Lewis Body Dementia, or another Lewy Body disease. Or nothing at all.

The more important research subject is what causes alpha synuclein to misfold and we know that this occurs primarily in the bowel, so let's look at how to take care of our gut and bowel better in early life.

Frankly, most of MJF research money is wasted on paying rich scientists to develop new drugs (very profitable) to treat symptoms that we can stop at the causes.

We don't need a "cure". We can already recover once we discover our individual causes and reverse those.

Less than 1% of research money is spent on health. 99% is spent on expensive medicine.

[MarionP in reply to crewmanwhite]

It wasn't a waste to the researchers, it probably put their kids through college and bought a second home in the Poconos and maybe a swimming pool. Very helpful to somebody, just not people with PD.

[Rupa88 in reply to MarionP]

👍👍👍👍

[kaypeeoh]

I assumed the DAT was diagnostic for PD. Why is the alpha-synuclein test better?