Topic #1) Intranasal Delivery of FGF-1 for the Treatment of Parkinson’s Disease and ALS (Motor Neuron Disease or Lou Gehrig’s disease)
Dr. Jacobs will be writing an in-depth report in the next section of this Update on our intranasal delivery of FGF-1 into the brain and those up-coming clinical trials. In his section he will cover (1) the animal data we have received that FGF-1 can be successfully delivered to the brain via the intranasal route, (2) our hypothesis on why we believe this treatment could succeed in treating Parkinson’s disease and ALS, (3) the planned human protocol for these clinical trials, and (4) how people can volunteer for consideration to participate in these clinical trials.
To Summarize Zhittya’s Position: The animal data we received on FGF-1 introduced into the nasal cavity and reached the brain successfully exceeded our highest expectations. We believe two to three weeks of administering the FGF-1 medicine into the nasal cavity (a snort in each nostril once a day followed by two minutes of normal breathing) is safe and has the potential to reverse Parkinson’s disease and ALS. We have purchased the devices for the intranasal delivery of our medicine and paid that manufacturer to program and set up the devices to deliver our medicine (FGF-1) for the two planned clinical trials in the Caribbean. We hope to have the devices ready to deliver our medicine in March 2022.
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EnterTheDragon
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Zhittya has a number of website entries that you can explore. Their concept/research is based on angiogenesis (growth) of capillaries in the targeted area (brain) so that neural tissue is properly nourished.The FG1 (growth factor) can be delivered via IV or intra-nasally.
I’ve found this particular line of research most interesting and have been following it for a number of years.
Looks promising to me, but only the long awaited human trials will provide us with evidence
"Our Hypothesis: Growing Blood Vessels and Nerves in the Brain Can Reverse Parkinson’s Disease
Parkinson’s disease is a neurological disease which results in the decline of the dopamine-producing neurons in the brain. When dopamine declines, a person will experience the symptoms of Parkinson’s disease. Recent research has shown that Parkinson’s patients have less blood flow to the part of the brain that has the dopamine-producing neurons. Animal tests have shown a reversal of Parkinson's symptoms with the introduction of the growth factor FGF-1. We know that FGF-1 has been shown to grow blood vessels and nerves, a process known as angiogenesis. We believe that if we can grow blood vessels and nerves in the brain where the dopamine-producing neurons reside, we should be able to reverse Parkinson’s disease."
(getting more blood to the brain is the logic I follow in taking Vinpocetine)
Bolt, I use Vinpocetine for the same reason. Is there anything else you know of or use for increasing blood flow to the brain? Ginko Biloba does but it decreases blood pressure. I don’t understand that. As I would think increasing blood pressure would be required to increase the blood flow to the brain? Anyways, if you kind of anything else for this purpose, please let me know. CC
If you have a hosepipe and tie some fishing line round it you will restrict the flow and increase the pressure. Cut the fish line, the pressure will drop and the flow increase. Basic shower installation knowledge any plumber would be aware of 🙄
I was replying to your last post, and it vanished. So I'll put it here
Oh Goodness. I like to keep things light - but certainly not to hurt people. Maybe you take things a bit too seriously. As we often say on my HiFi forum when people get too serious - "It's only a bloody record player!"
This was a thread about a potential new pharmaceutical candidate. OK , the company promoting it are unconventional (being kind), with a questionable track record (still being kind) and a stomach churning commercial-finance emphasis to all marketing (bit more of a spade is a spade). But this is about angiogenesis promoting neurogenesis. It's about a novel intranasal delivery device. It's about an alternative route (routes actually) to authorisation.
I have plenty of doubts, but as I have commented to some others on a private chat group we have - it's what in the UK we refer to as "piss or get off the pot". Instead of waiting until 2025 for the results of a gluten free diet, or the usual 15 year pipeline for drug development, we are either going to know it works and is safe, or know it doesn't within possibly 6 months - no more than 18 months. And if it works, it could provide very substantial therapeutic benefit to people like me, who actually have Parkinsons Disease (as opposed to wondering whether I might get it one day).
And if it works, apart from that putting pressure on the FDA and EMA for accelerated approval for their home markets, it is likely to be clinically available on a medical tourism basis within the same sort of timescales. Believe me, if you had Parkinsons Disease, that would be of serious interest to you.
Of course it might be bullshit - but , "piss or get off the pot", we're gonna know real soon.
It is not a thread about trying a few herbs to see if they increase blood flow to the brain. As I noted to Bolt - blood flow is like more cars down the freeway, but still no food in the suburbs. Angiogenesis is about building thousands of new local roads to reach the neighbourhoods.
And this is a forum for discussion - not a bloody public library reading room.
But like I said - whilst a bit of humour and banter is appreciated, I certainly wouldn't want to have hurt anyone. So let me see if I can answer your question a bit
I thought , in "researching" natural substances to increase bloodflow to the brain (missing the point about growing new blood vessels there) you asked about Gingko Bilbao being said to do that, but being associated with lower blood pressure, and asked how that could be. Surely lower blood pressure results in reduced blood flow.
Well, in a sealed pumped system, you can reduce pressure in at least 3 ways
1) as you pointed out - you can get the pump to pump less hard
2) you can change the viscosity of the fluid (thinner, less gluey liquid will flow more freely)
3) you can reduce the restriction of tight tubes - or dilate those tubes (or use a bigger bore hose pipe) . This is known as VASODILATION - and Gingko reduces blood pressure by increasing blood flow, by vasodilation
Think of filling your swimming pool with a regular garden hose, and compare it with doing it with a firemans hose. It's not the pressure in the firemans hose that fills the pool quicker, but the flow rate from the larger diameter pipe. I'm not sure what scientific authorities you require me to cite to satisfy you on this one, but if you take 2 2 gallon buckets, and draw a line at the level of 1 gallon, (you can't fill them, because the high pressure version is going to spray and splash). Take a regular garden hose and time how long it takes to fill the first bucket to the line. Then squeeze the hose between your finger and thumb and fill the 2nd bucket to the line. It will take longer - because squeezing the hose increases the pressure, but cuts the flow.
The fishing line as ligature on the hose idea suggested itself to me because my right eye is fitted with a Barveldt shunt tube. Following injuries, my right eye does not drain properly and gets dangerously over pressured. The Barveldt shunt is a thin tube inserted into the fluid chamber at the back of the lens, and connected to a plate on the sclera (the white of the eye) where the fluid is absorbed back into the general blood supply. The surgery requires several hours and a general anaesthetic, so they incorporate a post-surgical pressure regulation device. 3 bits of fishing line (joke!). They use 3 lasso sutures, tight, medium and loose along the length of the tube, which is visible just behind the eyelid. Then, they monitor the pressure, and if it is too high, they burn off the first ligature with a laser and dilate the tube a bit. If the pressure is still too high, then they burn off the next ligature. You get the idea
site sources if your going to respond telling me I’m wrong. Facts. Research. Opinions are the hypothesize upon which research is done. A layman’s hypothesize achieves little other than confusion. I’m not going to read your banter because I know given out history it contains put downs, sarcasm,, and I’m sure in there somewhere you remind me that “you’re too sensitive.” I do not want your opinion of my character.
I’m endeavoring to learn.
I will click a link if I see one but I will not read your responses anymore.
You know everything, that’s super! So your posts will always site your sources and be factual now, because, as you said, “ you know everything.” This will be a great change, Pooh. Who knew, underneath the sarcasm and long banter, all along you’ve known eveything. Sincerely, I know very little. I have a lot to learn and I’m really trying to learn.
Btw; when I saw a link I thought wow, might be worth a read for a change. Awesome!
Since you “know everything” please explain why your info you linked is opposite of the sources I sighted. I sincerely don’t understand and it’s important info for all of us. 😊
Have you read the information I responded with? Any facts or research to respond with? (Witty quips and eye rolls don’t help my research) But, if I and my research is incorrect, explain how please.
Oh wise one who has finally come forth as “one who knows everything.” Please, help with the endeavor to list all the relevant supplements , there method of action, compatibility, etc. I have posted about this many months ago and have been toiling away. Someone else is now pursuing this in earnest and I applaud and appreciate his efforts. Since you have proclaimed you “know everything.” I anxiously await your wisdom.
Did you read my post? This thread is about angiogenesis, nasal drug delivery, and overseas rapid drug approval trials. What relevance has your post to the subject matter of this thread?
Please stop thread crapping. And in the light of your private messages, sort your own problems out
well it's simple: just follow the context of WTP where the vascular system is like a tube and the brain would be a balloon full of water and the fishing line, ….I did not understand this well.
A very fantastic context that does not actually exist.
This tells me and you and all of us what a huge gap we suffer: in evaluating the data we lack familiarity with the real scene from which the data itself comes. Very illogical method. The web is full of these traps. Is there another method? Yes.
They are a disturbing, unorthodox (to be kind) bunch but their proposed therapy is a bit beyond increased blood flow. If increased blood flow is akin to doubling the number of cars on the freeway fgf-1 is about building hundreds of new side roads to reach the local houses
The present invention includes a method of treating Parkinson's disease in a patient comprising: administering a therapeutically effective amount of a FGF-115-155 and mutants thereof conjugated to a heparin (FGF-1), which is an amount sufficient to reduce or eliminate one or more symptoms associated with Parkinson's disease.
They are making some incredible claims. "A Revolutionary Medical Breakthrough to Treat These Diseases'"
I don't believe the cause of Parkinson's is solely a vascular disorder. "Parkinson’s might be a result of reduced blood flow to the brain..." Certainly, better blood flow in the brain is helpful which is the explanation for why exercise is so good, but I have my doubts that FGF-1 will grow new dopaminergic neurons in people.
Why did this company conduct trials in Mexico instead of the US?
I hope I am wrong about this, but too much-hype for my taste.
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